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ZFP91 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase [ Homo sapiens (human) ]

Gene ID: 80829, updated on 3-Nov-2024

Summary

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Official Symbol
ZFP91provided by HGNC
Official Full Name
ZFP91 zinc finger protein, atypical E3 ubiquitin ligaseprovided by HGNC
Primary source
HGNC:HGNC:14983
See related
Ensembl:ENSG00000186660 MIM:619289; AllianceGenome:HGNC:14983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
Summary
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
Expression
Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZFP91 in Genome Data Viewer
Location:
11q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58579063..58621550)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58528573..58571048)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58346536..58389023)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369313 Neighboring gene Sharpr-MPRA regulatory region 15251 Neighboring gene olfactory receptor family 5 subfamily B member 21 Neighboring gene leupaxin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58345528-58346220 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:58346914-58347605 Neighboring gene ZFP91-CNTF readthrough (NMD candidate) Neighboring gene ciliary neurotrophic factor Neighboring gene NANOG hESC enhancer GRCh37_chr11:58419172-58419673 Neighboring gene NANOG hESC enhancer GRCh37_chr11:58420305-58420859 Neighboring gene glycine-N-acyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer. Tang N, et al. Cell Prolif, 2021 May. PMID 33755268, Free PMC Article
  2. ZFP91-a newly described gene potentially involved in prostate pathology. Paschke L, et al. Pathol Oncol Res, 2014 Apr. PMID 24272675, Free PMC Article
  3. ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer. Paschke L, et al. Biomed Res Int, 2016. PMID 27975057, Free PMC Article
  4. A retroviral vector common integration site between leupaxin and zinc finger protein 91 (ZFP91) observed in baboon hematopoietic repopulating cells. Kiem HP, et al. Exp Hematol, 2010 Sep. PMID 20434516, Free PMC Article
  5. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy. Liu TT, et al. EBioMedicine, 2022 Dec. PMID 36375317, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.
    Title: Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.
  2. Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
    Title: Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
  3. Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
    Title: Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
  4. ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
    Title: ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
  5. MicroRNA1885p inhibits the progression of breast cancer by targeting zinc finger protein 91.
    Title: MicroRNA‑188‑5p inhibits the progression of breast cancer by targeting zinc finger protein 91.
  6. E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
    Title: E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
  7. Zinc finger protein 91 accelerates tumour progression by activating beta-catenin signalling in pancreatic cancer.
    Title: Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer.
  8. Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.
    Title: Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.
  9. The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.
    Title: The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.
  10. research describes a mechanism by which ZFP91 promotes production of IL-1beta under physiological conditions and suggests that ZFP91 may be a promising therapeutic target for intervention in inflammatory, infectious and autoimmune-related diseases
    Title: Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with zinc finger protein 91 homolog (ZFP91) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ57065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of NF-kappaB-inducing kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ZFP91
Names
RING-type E3 ubiquitin transferase ZFP91
drug resistance-associated sequence in melanoma 8
penta zinc finger protein
zinc finger protein 757
zinc finger protein 91 homolog
zinc finger protein homologous to Zfp91 in mouse
NP_001183980.1
NP_444251.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197051.2 → NP_001183980.1  E3 ubiquitin-protein ligase ZFP91 isoform 2

    See identical proteins and their annotated locations for NP_001183980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AB056107, AI687439, AP001350, BC051743, BP219969
    Conserved Domains (2) summary
    sd00017
    Location:346 → 365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:400 → 421
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_053023.5 → NP_444251.1  E3 ubiquitin-protein ligase ZFP91 isoform 1

    See identical proteins and their annotated locations for NP_444251.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB056107, AI687439, AP001350, BC051743, BP219969
    Consensus CDS
    CCDS31553.1
    UniProtKB/Swiss-Prot
    A6NHC4, A8MSG7, Q86V47, Q96JP4, Q96JP5, Q96QA3
    Related
    ENSP00000339030.5, ENST00000316059.7
    Conserved Domains (2) summary
    sd00017
    Location:347 → 366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:401 → 422
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    58579063..58621550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    58528573..58571048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JP5.1 GenPept UniProtKB/Swiss-Prot:Q96JP5

Gene LinkOut

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