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KCNH6 potassium voltage-gated channel subfamily H member 6 [ Homo sapiens (human) ]

Gene ID: 81033, updated on 10-Dec-2024

Summary

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Official Symbol
KCNH6provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily H member 6provided by HGNC
Primary source
HGNC:HGNC:18862
See related
Ensembl:ENSG00000173826 MIM:608168; AllianceGenome:HGNC:18862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERG2; ERG-2; HERG2; Kv11.2; hERG-2
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Expression
Biased expression in kidney (RPKM 3.1), small intestine (RPKM 1.8) and 4 other tissues See more
Orthologs
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Genomic context

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See KCNH6 in Genome Data Viewer
Location:
17q23.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (63523358..63548992)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (64393673..64419606)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61600719..61626353)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61563854-61564354 Neighboring gene angiotensin I converting enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12546 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:61594037-61595236 Neighboring gene angiotensin I converting enzyme 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61611272-61611775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:61626768-61627752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8820 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:61640093-61640313 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene RNA, U6 small nuclear 288, pseudogene Neighboring gene translational activator of cytochrome c oxidase I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition. Zhang YC, et al. Oxid Med Cell Longev, 2022. PMID 36217412, Free PMC Article
  2. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Zhao MM, et al. Nat Commun, 2021 Sep 23. PMID 34556670, Free PMC Article
  3. Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study. Yamoah K, et al. Prostate, 2021 Dec. PMID 34529278, Free PMC Article
  4. From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Yang JK, et al. Cell Rep, 2018 Dec 26. PMID 30590050
  5. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma. Wang M, et al. Biochem Biophys Res Commun, 2015 May 1. PMID 25783051

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
    Title: KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
  2. Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.
    Title: Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.
  3. Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.
    Title: Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.
  4. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
    Title: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
  5. dysfunction of KCNH6 causes overstimulation of insulin secretion in the short term and beta cell failure in the long term.
    Title: From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion.
  6. results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway
    Title: MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma.
  7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
  8. Transcripts for HERG1 were present in all adenomas and although transcripts for HERG2 and HERG3 were also detected, their expression level was more variable.
    Title: HERG K(+) currents in human prolactin-secreting adenoma cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in membrane repolarization during cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
voltage-gated inwardly rectifying potassium channel KCNH6; potassium voltage-gated channel subfamily H member 6
Names
eag-related gene member 2
ether-a-go-go-related protein 2
potassium channel, voltage gated eag related subfamily H, member 6
potassium voltage-gated channel, subfamily H (eag-related), member 6
voltage-gated potassium channel subunit Kv11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278919.2 → NP_001265848.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3

    See identical proteins and their annotated locations for NP_001265848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter, compared to isoform 1.
    Source sequence(s)
    AA825356, AK090969, AK296498, BE465143, BM561167, CD632730, DB147394, DB506421
    Consensus CDS
    CCDS62290.1
    UniProtKB/Swiss-Prot
    J9JID4, Q9BRD7, Q9H252
    UniProtKB/TrEMBL
    B4DKC0
    Related
    ENSP00000318212.5, ENST00000314672.10
    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  2. NM_001278920.2 → NP_001265849.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AA825356, AK090969, AK298363, BE465143, CD632730, DB506421
    UniProtKB/TrEMBL
    B4DPJ3
    Conserved Domains (4) summary
    COG0664
    Location:465 → 581
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:471 → 582
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:173 → 397
    Ion_trans; Ion transport protein
    pfam07885
    Location:340 → 394
    Ion_trans_2; Ion channel

  3. NM_030779.4 → NP_110406.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1

    See identical proteins and their annotated locations for NP_110406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA825356, AF311913, BE465143, CD632730, DB147394, DB506421
    Consensus CDS
    CCDS11638.1
    UniProtKB/TrEMBL
    B4DKC0
    Related
    ENSP00000463533.1, ENST00000583023.1
    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  4. NM_173092.4 → NP_775115.1  voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2

    See identical proteins and their annotated locations for NP_775115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment and an alternate in-frame exon but includes an alternate 3' terminal exon with an alternate 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter, compared to isoform 1.
    Source sequence(s)
    AC113554, AK091877, CD632730
    Consensus CDS
    CCDS11639.1
    UniProtKB/TrEMBL
    B4DKC0
    Related
    ENSP00000463830.1, ENST00000581784.5
    Conserved Domains (6) summary
    COG0664
    Location:535 → 651
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:541 → 652
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 467
    Ion_trans; Ion transport protein
    pfam07885
    Location:393 → 464
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    63523358..63548992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025175.2 → XP_016880664.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    UniProtKB/TrEMBL
    B4DKC0
    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  2. XM_017025177.2 → XP_016880666.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    UniProtKB/Swiss-Prot
    J9JID4, Q9BRD7, Q9H252
    UniProtKB/TrEMBL
    B4DKC0
    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  3. XM_047436856.1 → XP_047292812.1  potassium voltage-gated channel subfamily H member 6 isoform X11

    UniProtKB/TrEMBL
    B4DKC0

  4. XM_017025176.3 → XP_016880665.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    UniProtKB/TrEMBL
    B4DKC0

  5. XM_017025178.3 → XP_016880667.1  potassium voltage-gated channel subfamily H member 6 isoform X4

    UniProtKB/TrEMBL
    B4DKC0

  6. XM_017025179.3 → XP_016880668.1  potassium voltage-gated channel subfamily H member 6 isoform X5

    UniProtKB/TrEMBL
    B4DKC0

  7. XM_011525310.3 → XP_011523612.1  potassium voltage-gated channel subfamily H member 6 isoform X9

    See identical proteins and their annotated locations for XP_011523612.1

    UniProtKB/TrEMBL
    B4DKC0
    Related
    ENSP00000396900.2, ENST00000456941.6
    Conserved Domains (6) summary
    COG0664
    Location:535 → 651
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:541 → 652
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 467
    Ion_trans; Ion transport protein
    pfam07885
    Location:393 → 464
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  8. XM_047436854.1 → XP_047292810.1  potassium voltage-gated channel subfamily H member 6 isoform X6

    UniProtKB/TrEMBL
    B4DKC0

  9. XM_047436855.1 → XP_047292811.1  potassium voltage-gated channel subfamily H member 6 isoform X10

    UniProtKB/TrEMBL
    B4DKC0

  10. XM_017025180.3 → XP_016880669.1  potassium voltage-gated channel subfamily H member 6 isoform X12

    UniProtKB/TrEMBL
    B4DPJ3

  11. XM_011525309.3 → XP_011523611.1  potassium voltage-gated channel subfamily H member 6 isoform X8

    UniProtKB/TrEMBL
    B4DKC0
    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  12. XM_011525308.3 → XP_011523610.1  potassium voltage-gated channel subfamily H member 6 isoform X7

    UniProtKB/TrEMBL
    B4DKC0
    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  13. XM_011525311.2 → XP_011523613.1  potassium voltage-gated channel subfamily H member 6 isoform X13

    Conserved Domains (6) summary
    COG0664
    Location:588 → 724
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  14. XM_011525312.2 → XP_011523614.1  potassium voltage-gated channel subfamily H member 6 isoform X14

    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  15. XM_011525313.2 → XP_011523615.1  potassium voltage-gated channel subfamily H member 6 isoform X15

    Conserved Domains (6) summary
    COG0664
    Location:588 → 704
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

RNA

  1. XR_934568.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    64393673..64419606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317425.1 → XP_054173400.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    UniProtKB/TrEMBL
    B4DKC0

  2. XM_054317427.1 → XP_054173402.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    UniProtKB/TrEMBL
    B4DKC0

  3. XM_054317426.1 → XP_054173401.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    UniProtKB/TrEMBL
    B4DKC0

  4. XM_054317428.1 → XP_054173403.1  potassium voltage-gated channel subfamily H member 6 isoform X4

    UniProtKB/TrEMBL
    B4DKC0

  5. XM_054317429.1 → XP_054173404.1  potassium voltage-gated channel subfamily H member 6 isoform X5

    UniProtKB/TrEMBL
    B4DKC0

  6. XM_054317433.1 → XP_054173408.1  potassium voltage-gated channel subfamily H member 6 isoform X9

    UniProtKB/TrEMBL
    B4DKC0

  7. XM_054317430.1 → XP_054173405.1  potassium voltage-gated channel subfamily H member 6 isoform X6

    UniProtKB/TrEMBL
    B4DKC0

  8. XM_054317434.1 → XP_054173409.1  potassium voltage-gated channel subfamily H member 6 isoform X10

    UniProtKB/TrEMBL
    B4DKC0

  9. XM_054317436.1 → XP_054173411.1  potassium voltage-gated channel subfamily H member 6 isoform X12

    UniProtKB/TrEMBL
    B4DPJ3

  10. XM_054317435.1 → XP_054173410.1  potassium voltage-gated channel subfamily H member 6 isoform X11

    UniProtKB/TrEMBL
    B4DKC0

  11. XM_054317432.1 → XP_054173407.1  potassium voltage-gated channel subfamily H member 6 isoform X8

    UniProtKB/TrEMBL
    B4DKC0

  12. XM_054317431.1 → XP_054173406.1  potassium voltage-gated channel subfamily H member 6 isoform X7

    UniProtKB/TrEMBL
    B4DKC0

  13. XM_054317437.1 → XP_054173412.1  potassium voltage-gated channel subfamily H member 6 isoform X13

  14. XM_054317438.1 → XP_054173413.1  potassium voltage-gated channel subfamily H member 6 isoform X14

  15. XM_054317439.1 → XP_054173414.1  potassium voltage-gated channel subfamily H member 6 isoform X15

RNA

  1. XR_008484947.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H252.2 GenPept UniProtKB/Swiss-Prot:Q9H252

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