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FIP1L1 factor interacting with PAPOLA and CPSF1 [ Homo sapiens (human) ]

Gene ID: 81608, updated on 3-Nov-2024

Summary

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Official Symbol
FIP1L1provided by HGNC
Official Full Name
factor interacting with PAPOLA and CPSF1provided by HGNC
Primary source
HGNC:HGNC:19124
See related
Ensembl:ENSG00000145216 MIM:607686; AllianceGenome:HGNC:19124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rhe; FIP1; hFip1
Summary
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in testis (RPKM 13.3), brain (RPKM 11.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FIP1L1 in Genome Data Viewer
Location:
4q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (53377641..53460862)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (56864883..56948080)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (54243808..54327029)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sec1 family domain containing 2 Neighboring gene uncharacterized LOC124900701 Neighboring gene VISTA enhancer hs1668 Neighboring gene VISTA enhancer hs1460 Neighboring gene NANOG hESC enhancer GRCh37_chr4:54102933-54103444 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:54103445-54103956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54122352-54122863 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:54140029-54140243 Neighboring gene RNA, U6 small nuclear 310, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:54195258-54195835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21561 Neighboring gene uncharacterized LOC105377654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54243526-54244074 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54244075-54244623 Neighboring gene LNX1 antisense RNA 1 Neighboring gene ligand of numb-protein X 1 Neighboring gene COMMD5 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance. Gorantla SP, et al. Leukemia, 2015 Aug. PMID 25761934
  2. FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia. Iwasaki J, et al. Ann Hematol, 2014 Sep. PMID 24763514
  3. Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis. Muckenfuss LM, et al. Elife, 2022 Sep 8. PMID 36073787, Free PMC Article
  4. Myeloid neoplasm with eosinophilia associated with isolated extramedullary FIP1L1/PDGFRA rearrangement. Hilal T, et al. Cancer Genet, 2018 Jan. PMID 29310833
  5. Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis. Skarp S, et al. PLoS One, 2018. PMID 30157244, Free PMC Article

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
    Title: Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
  2. FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction.
    Title: FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction.
  3. Exquisite response to imatinib mesylate in FIP1L1-PDGFRA-mutated hypereosinophilic syndrome: a 12-year experience of the Polish Hypereosinophilic Syndrome Study Group.
    Title: Exquisite response to imatinib mesylate in FIP1L1-PDGFRA-mutated hypereosinophilic syndrome: a 12-year experience of the Polish Hypereosinophilic Syndrome Study Group.
  4. Two identified variants revealed novel candidate genes for hip and knee osteoarthritis. OLIG3 and FIP1L1 have specific roles in transcription and may effect expression of other genes. Identified variants in these genes may thus have a role in the regulatory events leading to osteoarthritis.
    Title: Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.
  5. Herein, we report a case of a 53-year-old man with eosinophilia and a well-differentiated extramedullary myeloid tumor with evidence of FIP1L1/PDGFRA rearrangement by fluorescent in situ hybridization in the extramedullary tissue.
    Title: Myeloid neoplasm with eosinophilia associated with isolated extramedullary FIP1L1/PDGFRA rearrangement.
  6. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation.
    Title: Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
  7. Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1-PDGFRA gene fusion.
    Title: Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene.
  8. FIP1L1/ PDGFRA associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.
    Title: Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in China.
  9. F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.
    Title: F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance.
  10. FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.
    Title: FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
EBI GWAS Catalog
Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33619, DKFZp586K0717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
pre-mRNA 3'-end-processing factor FIP1
Names
FIP1 like 1
FIP1-like 1 protein
FIP1L1 cleavage and polyadenylation specific factor subunit
factor interacting with PAP
rearranged in hypereosinophilia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008644.1 RefSeqGene

    Range
    4989..88210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134937.2 → NP_001128409.1  pre-mRNA 3'-end-processing factor FIP1 isoform 2

    See identical proteins and their annotated locations for NP_001128409.1

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS47055.1
    UniProtKB/TrEMBL
    A0A994J6C9
    Related
    ENSP00000351383.5, ENST00000358575.9
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  2. NM_001134938.2 → NP_001128410.1  pre-mRNA 3'-end-processing factor FIP1 isoform 3

    See identical proteins and their annotated locations for NP_001128410.1

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS47056.1
    UniProtKB/TrEMBL
    A0A994J6P8
    Related
    ENSP00000302993.6, ENST00000306932.10
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  3. NM_001376744.1 → NP_001363673.1  pre-mRNA 3'-end-processing factor FIP1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6C9
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  4. NM_001376745.1 → NP_001363674.1  pre-mRNA 3'-end-processing factor FIP1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93495.1
    UniProtKB/TrEMBL
    A0A994J6B4, A0A994J6C9
    Related
    ENSP00000515305.1, ENST00000703454.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  5. NM_001376746.1 → NP_001363675.1  pre-mRNA 3'-end-processing factor FIP1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93499.1
    UniProtKB/TrEMBL
    A0A994J3L5, A0A994J6C9
    Related
    ENSP00000515334.1, ENST00000703484.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  6. NM_001376747.1 → NP_001363676.1  pre-mRNA 3'-end-processing factor FIP1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93504.1
    UniProtKB/TrEMBL
    A0A994J3L0, A0A994J6D6
    Related
    ENSP00000515335.1, ENST00000703485.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  7. NM_001376748.1 → NP_001363677.1  pre-mRNA 3'-end-processing factor FIP1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93503.1
    UniProtKB/TrEMBL
    A0A994J469, A0A994J6P8
    Related
    ENSP00000515336.1, ENST00000703486.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  8. NM_001376749.1 → NP_001363678.1  pre-mRNA 3'-end-processing factor FIP1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93501.1
    UniProtKB/TrEMBL
    A0A994J3I9, A0A994J6C9
    Related
    ENSP00000515304.1, ENST00000703453.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  9. NM_001376750.1 → NP_001363679.1  pre-mRNA 3'-end-processing factor FIP1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93515.1
    UniProtKB/TrEMBL
    A0A994J458, A0A994J6C9
    Related
    ENSP00000515326.1, ENST00000703475.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  10. NM_001376751.1 → NP_001363680.1  pre-mRNA 3'-end-processing factor FIP1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93510.1
    UniProtKB/TrEMBL
    A0A994J6C9, A0A994J6R0
    Related
    ENSP00000515333.1, ENST00000703483.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  11. NM_001376752.1 → NP_001363681.1  pre-mRNA 3'-end-processing factor FIP1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93502.1
    UniProtKB/TrEMBL
    A0A994J464, A0A994J6C9
    Related
    ENSP00000515331.1, ENST00000703481.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  12. NM_001376753.1 → NP_001363682.1  pre-mRNA 3'-end-processing factor FIP1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6P8
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  13. NM_001376754.1 → NP_001363683.1  pre-mRNA 3'-end-processing factor FIP1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93506.1
    UniProtKB/TrEMBL
    A0A994J474, A0A994J6C9
    Related
    ENSP00000515342.1, ENST00000703492.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  14. NM_001376755.1 → NP_001363684.1  pre-mRNA 3'-end-processing factor FIP1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93512.1
    UniProtKB/TrEMBL
    A0A994J3T5, A0A994J6C9
    Related
    ENSP00000515343.1, ENST00000703497.1
    Conserved Domains (1) summary
    pfam05182
    Location:153 → 195
    Fip1; Fip1 motif

  15. NM_001376756.1 → NP_001363685.1  pre-mRNA 3'-end-processing factor FIP1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6C9
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  16. NM_001376757.1 → NP_001363686.1  pre-mRNA 3'-end-processing factor FIP1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J3L0
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  17. NM_001376758.1 → NP_001363687.1  pre-mRNA 3'-end-processing factor FIP1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93519.1
    UniProtKB/TrEMBL
    A0A994J453, A0A994J6P8
    Related
    ENSP00000515321.1, ENST00000703470.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  18. NM_001376759.1 → NP_001363688.1  pre-mRNA 3'-end-processing factor FIP1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93497.1
    UniProtKB/TrEMBL
    A0A994J3S0, A0A994J6P8
    Related
    ENSP00000515327.1, ENST00000703476.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  19. NM_001376760.1 → NP_001363689.1  pre-mRNA 3'-end-processing factor FIP1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93518.1
    UniProtKB/TrEMBL
    A0A994J6C9, A0A994J6N5
    Related
    ENSP00000515303.1, ENST00000703452.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  20. NM_001376761.1 → NP_001363690.1  pre-mRNA 3'-end-processing factor FIP1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93500.1
    UniProtKB/TrEMBL
    A0A994J3S6, A0A994J6P8
    Related
    ENSP00000515332.1, ENST00000703482.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  21. NM_001376762.1 → NP_001363691.1  pre-mRNA 3'-end-processing factor FIP1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6C9
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  22. NM_001376764.1 → NP_001363693.1  pre-mRNA 3'-end-processing factor FIP1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93524.1
    UniProtKB/TrEMBL
    A0A994J442, A0A994J6C9
    Related
    ENSP00000515311.1, ENST00000703460.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  23. NM_001376765.1 → NP_001363694.1  pre-mRNA 3'-end-processing factor FIP1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93498.1
    UniProtKB/TrEMBL
    A0A994J3M0, A0A994J6P8
    Related
    ENSP00000515340.1, ENST00000703490.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  24. NM_001376766.1 → NP_001363695.1  pre-mRNA 3'-end-processing factor FIP1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93496.1
    UniProtKB/TrEMBL
    A0A994J3L0, A0A994J3Q0
    Related
    ENSP00000515307.1, ENST00000703456.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  25. NM_001376767.1 → NP_001363696.1  pre-mRNA 3'-end-processing factor FIP1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93520.1
    UniProtKB/TrEMBL
    A0A994J6C9, A0A994J6P0
    Related
    ENSP00000515308.1, ENST00000703457.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  26. NM_001376768.1 → NP_001363697.1  pre-mRNA 3'-end-processing factor FIP1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93525.1
    UniProtKB/TrEMBL
    A0A994J3K5, A0A994J6C9
    Related
    ENSP00000515324.1, ENST00000703473.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  27. NM_001376769.1 → NP_001363698.1  pre-mRNA 3'-end-processing factor FIP1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93516.1
    UniProtKB/TrEMBL
    A0A994J3R0, A0A994J6P8
    Related
    ENSP00000515317.1, ENST00000703466.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  28. NM_001376770.1 → NP_001363699.1  pre-mRNA 3'-end-processing factor FIP1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J3L0
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  29. NM_001376771.1 → NP_001363700.1  pre-mRNA 3'-end-processing factor FIP1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93507.1
    UniProtKB/TrEMBL
    A0A994J438, A0A994J6P8
    Related
    ENSP00000515306.1, ENST00000703455.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  30. NM_001376772.1 → NP_001363701.1  pre-mRNA 3'-end-processing factor FIP1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93511.1
    UniProtKB/TrEMBL
    A0A994J6C9, A0A994J6E2
    Related
    ENSP00000515346.1, ENST00000703500.1
    Conserved Domains (1) summary
    pfam05182
    Location:133 → 160
    Fip1; Fip1 motif

  31. NM_001376773.1 → NP_001363702.1  pre-mRNA 3'-end-processing factor FIP1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93517.1
    UniProtKB/TrEMBL
    A0A994J3P6, A0A994J6P8
    Related
    ENSP00000515302.1, ENST00000703451.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  32. NM_001376774.1 → NP_001363703.1  pre-mRNA 3'-end-processing factor FIP1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6P8
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  33. NM_001376775.1 → NP_001363704.1  pre-mRNA 3'-end-processing factor FIP1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93509.1
    UniProtKB/TrEMBL
    A0A994J6E0, A0A994J6P8
    Related
    ENSP00000515341.1, ENST00000703491.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  34. NM_001376776.1 → NP_001363705.1  pre-mRNA 3'-end-processing factor FIP1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J3L0
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  35. NM_001376777.1 → NP_001363706.1  pre-mRNA 3'-end-processing factor FIP1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6P8
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  36. NM_001376778.1 → NP_001363707.1  pre-mRNA 3'-end-processing factor FIP1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93522.1
    UniProtKB/TrEMBL
    A0A994J6P8, H0Y8P7
    Related
    ENSP00000421691.2, ENST00000504094.2
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  37. NM_001376779.1 → NP_001363708.1  pre-mRNA 3'-end-processing factor FIP1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93521.1
    UniProtKB/TrEMBL
    A0A994J3J1, A0A994J6P8
    Related
    ENSP00000515309.1, ENST00000703458.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  38. NM_001376780.1 → NP_001363709.1  pre-mRNA 3'-end-processing factor FIP1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93526.1
    UniProtKB/TrEMBL
    A0A994J3R5, A0A994J6P8
    Related
    ENSP00000515322.1, ENST00000703471.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  39. NM_001376781.1 → NP_001363710.1  pre-mRNA 3'-end-processing factor FIP1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93523.1
    UniProtKB/TrEMBL
    A0A994J3K1, A0A994J6P8
    Related
    ENSP00000515319.1, ENST00000703468.1
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  40. NM_001376782.1 → NP_001363711.1  pre-mRNA 3'-end-processing factor FIP1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6P8
    Conserved Domains (1) summary
    pfam05182
    Location:115 → 157
    Fip1; Fip1 motif

  41. NM_001376783.1 → NP_001363712.1  pre-mRNA 3'-end-processing factor FIP1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6P8
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  42. NM_001376784.1 → NP_001363713.1  pre-mRNA 3'-end-processing factor FIP1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J3L0
    Conserved Domains (1) summary
    pfam05182
    Location:139 → 181
    Fip1; Fip1 motif

  43. NM_001376785.1 → NP_001363714.1  pre-mRNA 3'-end-processing factor FIP1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    UniProtKB/TrEMBL
    A0A994J6C9

  44. NM_001376786.1 → NP_001363715.1  pre-mRNA 3'-end-processing factor FIP1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93508.1
    UniProtKB/TrEMBL
    A0A994J3L0, A0A994J6Q5
    Related
    ENSP00000515328.1, ENST00000703478.1
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  45. NM_001410723.1 → NP_001397652.1  pre-mRNA 3'-end-processing factor FIP1 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93513.1
    UniProtKB/TrEMBL
    A0A994J6C6
    Related
    ENSP00000515320.1, ENST00000703469.1

  46. NM_001410724.1 → NP_001397653.1  pre-mRNA 3'-end-processing factor FIP1 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS93514.1
    UniProtKB/TrEMBL
    A0A994J3Q5
    Related
    ENSP00000515312.1, ENST00000703461.1

  47. NM_030917.4 → NP_112179.2  pre-mRNA 3'-end-processing factor FIP1 isoform 1

    See identical proteins and their annotated locations for NP_112179.2

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821, AY366510, DN990103
    Consensus CDS
    CCDS3491.1
    UniProtKB/Swiss-Prot
    B4DIR3, G3XAD6, Q0VGE0, Q499Y4, Q49AU3, Q6UN15, Q7Z608, Q8WVN3, Q96F80, Q9H077
    UniProtKB/TrEMBL
    A0A994J6C9
    Related
    ENSP00000336752.6, ENST00000337488.11
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

RNA

  1. NR_164847.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821

  2. NR_164848.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821

  3. NR_164849.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    53377641..53460862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416208.1 → XP_047272164.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

  2. XM_005265779.5 → XP_005265836.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

    UniProtKB/TrEMBL
    A0A994J3L0
    Conserved Domains (1) summary
    pfam05182
    Location:154 → 196
    Fip1; Fip1 motif

  3. XM_047416211.1 → XP_047272167.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

  4. XM_047416212.1 → XP_047272168.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

  5. XM_047416218.1 → XP_047272174.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

    UniProtKB/TrEMBL
    A0A994J6D3
    Related
    ENSP00000515330.1, ENST00000703480.1

  6. XM_047416215.1 → XP_047272171.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

  7. XM_047416210.1 → XP_047272166.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

  8. XM_047416214.1 → XP_047272170.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

  9. XM_047416216.1 → XP_047272172.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

  10. XM_047416213.1 → XP_047272169.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    56864883..56948080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350921.1 → XP_054206896.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

  2. XM_054350927.1 → XP_054206902.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

  3. XM_054350923.1 → XP_054206898.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

  4. XM_054350924.1 → XP_054206899.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

  5. XM_054350930.1 → XP_054206905.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

    UniProtKB/TrEMBL
    A0A994J6D3

  6. XM_054350928.1 → XP_054206903.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

  7. XM_054350922.1 → XP_054206897.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

  8. XM_054350926.1 → XP_054206901.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

  9. XM_054350929.1 → XP_054206904.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

  10. XM_054350925.1 → XP_054206900.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UN15.1 GenPept UniProtKB/Swiss-Prot:Q6UN15

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