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Gpt glutamic--pyruvic transaminase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81670, updated on 17-Aug-2024

Summary

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Official Symbol
Gptprovided by RGD
Official Full Name
glutamic--pyruvic transaminaseprovided by RGD
Primary source
RGD:621720
See related
EnsemblRapid:ENSRNOG00000033915 AllianceGenome:RGD:621720
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ALAT; Gpt1
Summary
Involved in cellular response to insulin stimulus; positive regulation of gluconeogenesis; and response to starvation. Located in cytoplasm and extracellular space. Biomarker of type 2 diabetes mellitus. Orthologous to human GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 322.2), Lung (RPKM 201.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110295599..110300134)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108416646..108419495)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117759083..117761932)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ like helicase 4 Neighboring gene leucine rich repeat containing 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation. Kim HJ, et al. Korean J Intern Med, 2020 Mar. PMID 30665287, Free PMC Article
  2. Clinical relevance of reporting fatty liver on ultrasound in asymptomatic patients during routine health checkups. Mahale AR, et al. J Int Med Res, 2018 Nov. PMID 30185098, Free PMC Article
  3. Hepatitis B virus e antigen-negative chronic infection. Treatment based on glutamic pyruvic transaminase and hepatitis B virus deoxyribonucleic acid cut-off values. Guardiola-Arévalo A, et al. Gastroenterol Hepatol, 2018 Mar. PMID 29279233
  4. Effects of saikosaponins on hepatic damage induced by halothane and hypoxia in phenobarbital-pretreated rats. Nishiura T, et al. J Anesth, 1994 Mar. PMID 28921207
  5. ANTIOXIDANT ACTIVITY IN VITRO AND HEPATOPROTECTIVE EFFECTS IN VIVO OF COMPOUND LOBELIA. Cui X, et al. Afr J Tradit Complement Altern Med, 2016. PMID 28487901, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that AZD4619 increased alanine aminotransferase (ALT1) protein expression in a dose-dependent manner in human, but not in rat hepatocytes.
    Title: The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels.
  2. Data suggest that both Alt1 and Alt2 are induced in liver during gluconeogenesis and in diabetes (Goto-Kakizaki rats); in hepatocytes, both Alt1 and Alt2 are induced by glucocorticoid dexamethasone and are suppressed by insulin.
    Title: Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.
  3. Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
    Title: The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
  4. Protein levels are significantly elevated and correlate with activity, providing the molecular basis for the elevated total serum enzyme activity in liver toxicity.
    Title: Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
  5. Report the early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
    Title: The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-alanine:2-oxoglutarate aminotransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables pyridoxal phosphate binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alanine aminotransferase 1
Names
ALT1
GPT 1
glutamate pyruvate transaminase 1
glutamic pyruvate transaminase
glutamic pyruvic transaminase (alanine aminotrasferase)
glutamic pyruvic transaminase 1, soluble
glutamic--alanine transaminase 1
glutamic--pyruvic transaminase 1
glutamic-pyruvate transaminase (alanine aminotransferase)
NP_112301.1
XP_063120365.1
XP_063120366.1
XP_063120367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031039.2 → NP_112301.1  alanine aminotransferase 1

    See identical proteins and their annotated locations for NP_112301.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P25409, Q4V7F7
    UniProtKB/TrEMBL
    A6HSC5, A6HSC6
    Conserved Domains (2) summary
    cd00609
    Location:98 → 473
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:19 → 496
    PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110295599..110300134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264295.1 → XP_063120365.1  alanine aminotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P25409, Q4V7F7
    UniProtKB/TrEMBL
    A6HSC5, A6HSC6

  2. XM_063264296.1 → XP_063120366.1  alanine aminotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P25409, Q4V7F7
    UniProtKB/TrEMBL
    A6HSC5, A6HSC6
    Related
    ENSRNOT00000050556.5

  3. XM_063264297.1 → XP_063120367.1  alanine aminotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P25409, Q4V7F7
    UniProtKB/TrEMBL
    A6HSC5, A6HSC6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25409.2 GenPept UniProtKB/Swiss-Prot:P25409

Gene LinkOut

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