U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Suox sulfite oxidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81805, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Suoxprovided by RGD
Official Full Name
sulfite oxidaseprovided by RGD
Primary source
RGD:619994
See related
EnsemblRapid:ENSRNOG00000005987 AllianceGenome:RGD:619994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Involved in response to nutrient. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 42.9), Kidney (RPKM 39.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Suox in Genome Data Viewer
Location:
7q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1687666..1691759, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1103149..1107156, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3098228..3102179, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 1, pseudogene 1 Neighboring gene ribosomal protein S26 Neighboring gene IKAROS family zinc finger 4 Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC120093528 Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxidase competent and deficient rats. Kucukatay V, et al. Int J Neurosci, 2007 Jul. PMID 17613108
  2. Molecular cloning of rat liver sulfite oxidase. Expression of a eukaryotic Mo-pterin-containing enzyme in Escherichia coli. Garrett RM, et al. J Biol Chem, 1994 Jan 7. PMID 8276806
  3. Biosynthesis of sulfite oxidase in rat liver - presence of a large precursor form of the enzyme in cytosol. Ono H, et al. J Biochem, 1982 Jan. PMID 7068556
  4. Transport of the precursor for sulfite oxidase into intermembrane space of liver mitochondria: characterization of import and processing activities. Ono H, et al. J Biochem, 1984 Feb. PMID 6715303
  5. Evidence for participation of the inner membrane in the import of sulfite oxidase into the intermembrane space of liver mitochondria. Ono H, et al. Biochem Biophys Res Commun, 1982 Jul 16. PMID 6181785

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfite oxidase gene expression in brain and in other tissues.
    Title: Sulphite oxidase gene expression in human brain and in other human and rat tissues.
  2. Results suggest that hippocampus antioxidant enzymes (defense mechanism against the oxidative challenge) are up-regulated by ingested sulfites in sulfite oxidase competent rats.
    Title: Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxidase competent and deficient rats.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfite oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfite oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfite oxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfur compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sulfite oxidase, mitochondrial
NP_112389.3
XP_006240864.1
XP_006240865.1
XP_063120370.1
XP_063120371.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031127.4 → NP_112389.3  sulfite oxidase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_112389.3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q07116, Q6P6W0
    UniProtKB/TrEMBL
    A6KSG5, G3V6R5
    Related
    ENSRNOP00000008018.3, ENSRNOT00000008018.7
    Conserved Domains (3) summary
    PLN00177
    Location:169 → 544
    PLN00177; sulfite oxidase; Provisional
    cd02111
    Location:186 → 544
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:85 → 161
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1687666..1691759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240802.5 → XP_006240864.1  sulfite oxidase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006240864.1

    UniProtKB/Swiss-Prot
    Q07116, Q6P6W0
    UniProtKB/TrEMBL
    A6KSG5, G3V6R5
    Conserved Domains (3) summary
    PLN00177
    Location:169 → 544
    PLN00177; sulfite oxidase; Provisional
    cd02111
    Location:186 → 544
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:85 → 161
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

  2. XM_006240803.5 → XP_006240865.1  sulfite oxidase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006240865.1

    UniProtKB/Swiss-Prot
    Q07116, Q6P6W0
    UniProtKB/TrEMBL
    A6KSG5, G3V6R5
    Conserved Domains (3) summary
    PLN00177
    Location:169 → 544
    PLN00177; sulfite oxidase; Provisional
    cd02111
    Location:186 → 544
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:85 → 161
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

  3. XM_063264301.1 → XP_063120371.1  sulfite oxidase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6KSG5, G3V6R5

  4. XM_063264300.1 → XP_063120370.1  sulfite oxidase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6KSG5, G3V6R5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07116.2 GenPept UniProtKB/Swiss-Prot:Q07116

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous