Serpina7 serpin family A member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpina7provided by RGD
Official Full Name: serpin family A member 7provided by RGD
Primary source: RGD:619833
See related: EnsemblRapid:ENSRNOG00000011081 AllianceGenome:RGD:619833
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tbg
Summary: Enables hormone binding activity. Involved in several processes, including response to corticosterone; response to prostaglandin E; and response to vitamin A. Located in extracellular space. Biomarker of hyperthyroidism and hypothyroidism. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 213.8) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (107452044..107510958, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (102663242..102722319, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (110226565..110232202, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene expressions of ELOVL6 and SPC24 were upregulated, and SERPINA7 was downregulated in the livers of rats with ventromedial hypothalamic lesions.
Title: Gene expression profiling in rat liver after VMH lesioning.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables thyroid hormone transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to prostaglandin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: thyroxine-binding globulin

Names: T4-binding globulin; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serpin A7; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031128.1 → NP_112390.1 thyroxine-binding globulin precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P35577

UniProtKB/TrEMBL

A0A140TAB0, A6KNW8

Related

ENSRNOP00000014739.5, ENSRNOT00000014739.8

Conserved Domains (1) summary

cd19555
Location:48 → 425

serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

107452044..107510958 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100095.2 → XP_038956023.1 thyroxine-binding globulin isoform X7

Conserved Domains (1) summary

cl38926
Location:1 → 217

serpin; SERine Proteinase INhibitors (serpin) family
XM_039100093.2 → XP_038956021.1 thyroxine-binding globulin isoform X6

Conserved Domains (1) summary

cl38926
Location:48 → 218

serpin; SERine Proteinase INhibitors (serpin) family
XM_039100092.2 → XP_038956020.1 thyroxine-binding globulin isoform X3

UniProtKB/TrEMBL

A0A1W2Q6F2

Related

ENSRNOP00000076228.2, ENSRNOT00000093401.3

Conserved Domains (1) summary

cl38926
Location:4 → 248

serpin; SERine Proteinase INhibitors (serpin) family
XM_039100091.2 → XP_038956019.1 thyroxine-binding globulin isoform X2

UniProtKB/TrEMBL

A0A1W2Q6F2

Conserved Domains (1) summary

cl38926
Location:4 → 258

serpin; SERine Proteinase INhibitors (serpin) family
XM_063280328.1 → XP_063136398.1 thyroxine-binding globulin isoform X1
XM_063280329.1 → XP_063136399.1 thyroxine-binding globulin isoform X4
XM_063280330.1 → XP_063136400.1 thyroxine-binding globulin isoform X5