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USP11 ubiquitin specific peptidase 11 [ Homo sapiens (human) ]

Gene ID: 8237, updated on 2-Nov-2024

Summary

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Official Symbol
USP11provided by HGNC
Official Full Name
ubiquitin specific peptidase 11provided by HGNC
Primary source
HGNC:HGNC:12609
See related
Ensembl:ENSG00000102226 MIM:300050; AllianceGenome:HGNC:12609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UHX1
Summary
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 81.8), ovary (RPKM 32.3) and 22 other tissues See more
Orthologs
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Genomic context

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See USP11 in Genome Data Viewer
Location:
Xp11.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (47233009..47248328)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (46642700..46657954)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47092408..47107727)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ubiquitin like modifier activating enzyme 1 Neighboring gene uncharacterized LOC105373194 Neighboring gene inactivation escape 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29587 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:47078167-47078806 Neighboring gene cyclin dependent kinase 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:47087788-47088288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:47088289-47088789 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element 1 Neighboring gene small nucleolar RNA U13 Neighboring gene nicolin 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders. Swanson DA, et al. Hum Mol Genet, 1996 Apr. PMID 8845848
  2. Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma. Zhang S, et al. Lab Invest, 2018 Jul. PMID 29545598
  3. USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity. Pornour M, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39052835,
  4. Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11. Spiliotopoulos A, et al. J Biol Chem, 2019 Jan 11. PMID 30373771, Free PMC Article
  5. Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains. Harper S, et al. Biochemistry, 2014 May 13. PMID 24724799, Free PMC Article

See all (194) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.
    Title: USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.
  2. USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/beta-catenin signaling pathway.
    Title: USP11 regulates proliferation and apoptosis of human spermatogonial stem cells via HOXC5-mediated canonical WNT/β-catenin signaling pathway.
  3. Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-beta receptorII.
    Title: Ubiquitin-specific peptidase 11 promotes development of keloid derived fibroblasts by de-ubiquitinating TGF-β receptorII.
  4. DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.
    Title: DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.
  5. USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.
    Title: USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.
  6. USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1.
    Title: USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1.
  7. The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.
    Title: The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.
  8. USP11 plays a critical role in the onset and progression of acute graft-versus-host diseaseNovel target for precision therapeutics.
    Title: USP11 plays a critical role in the onset and progression of acute graft-versus-host disease：Novel target for precision therapeutics.
  9. Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.
    Title: Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.
  10. X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
    Title: X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with ubiquitin specific peptidase 11 (USP11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 11
Names
deubiquitinating enzyme 11
ubiquitin carboxyl-terminal hydrolase, X-linked
ubiquitin thioesterase 11
ubiquitin thiolesterase 11
ubiquitin-specific processing protease 11
NP_001358001.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012546.1 RefSeqGene

    Range
    5095..20414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001371072.1 → NP_001358001.1  ubiquitin carboxyl-terminal hydrolase 11

    Status: VALIDATED

    Source sequence(s)
    AB073597, BC140849
    Consensus CDS
    CCDS14277.2
    UniProtKB/TrEMBL
    G5E9A6, Q6P453
    Related
    ENSP00000366311.2, ENST00000377107.7
    Conserved Domains (1) summary
    COG5560
    Location:56 → 886
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    47233009..47248328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    46642700..46657954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004651.3: Suppressed sequence

    Description
    NM_004651.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51784.3 GenPept UniProtKB/Swiss-Prot:P51784

Gene LinkOut

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