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DFB DHFS-FPGS homolog B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830484, updated on 18-Sep-2024

Summary

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Official Symbol
DFB
Official Full Name
DHFS-FPGS homolog B
Primary source
TAIR:AT5G05980
Locus tag
AT5G05980
See related
Araport:AT5G05980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATDFB; DHFS-FPGS homolog B; folylpolyglutamate synthetase 1; FPGS1; K18J17.17; K18J17_17
Summary
Encodes one of the three folylpolyglutamate synthetase isoforms (FPGSs): FPGS1 (At5g05980, plastidic), FPGS2 (At3g10160, mitochondrial) and FPGS3 (At3g55630, cytosolic).
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Genomic context

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See DFB in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Sequence:
Chromosome: 5; NC_003076.8 (1799490..1804492, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene maternal effect embryo arrest 60 Neighboring gene cell wall RBR3-like protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene prenylated RAB acceptor 1.A2 Neighboring gene Mitochondrial glycoprotein family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness. Meng H, et al. Biochem Biophys Res Commun, 2017 Jan 8. PMID 27845046
  2. The plastidial folylpolyglutamate synthetase and root apical meristem maintenance. Srivastava AC, et al. Plant Signal Behav, 2011 May. PMID 21502816, Free PMC Article
  3. Combining loss of function of FOLYLPOLYGLUTAMATE SYNTHETASE1 and CAFFEOYL-COA 3-O-METHYLTRANSFERASE1 for lignin reduction and improved saccharification efficiency in Arabidopsis thaliana. Xie H, et al. Biotechnol Biofuels, 2019. PMID 31073332, Free PMC Article
  4. The folylpolyglutamate synthetase plastidial isoform is required for postembryonic root development in Arabidopsis. Srivastava AC, et al. Plant Physiol, 2011 Mar. PMID 21233333, Free PMC Article
  5. Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis. Zhou HR, et al. Plant Cell, 2013 Jul. PMID 23881414, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, these results indicated that intact folate metabolism was necessary for nitrogen metabolism in Arabidopsis thaliana under nitrate-limited condition in darkness, providing novel insights into function of folate.
    Title: Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness.
  2. Data indicates that intact folate metabolism was necessary for nitrogen metabolism in Arabidopsis thaliana under nitrate-limited condition in darkness.
    Title: Arabidopsis plastidial folylpolyglutamate synthetase is required for nitrogen metabolism under nitrate-limited condition in darkness.
  3. Data indicate that H3K9 dimethylation level in mutants ros1 fpgs1 (folylpolyglutamate synthase 1) was clearly reduced.
    Title: Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis.
  4. Mutants in the AtDFB (At5G05980) gene disrupt primary root development in Arabidopsis thaliana seedlings.
    Title: The plastidial folylpolyglutamate synthetase and root apical meristem maintenance.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001036763.2
NM_120680.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables tetrahydrofolylpolyglutamate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables tetrahydrofolylpolyglutamate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lignin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within one-carbon metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within quiescent center organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root hair elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tetrahydrofolylpolyglutamate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DHFS-FPGS homolog B
NP_001031840.1
  • DHFS-FPGS homolog B (DFB); CONTAINS InterPro DOMAIN/s: Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog D (TAIR:AT3G55630.3); Has 7710 Blast hits to 7708 proteins in 2543 species: Archae - 43; Bacteria - 4850; Metazoa - 165; Fungi - 360; Plants - 132; Viruses - 0; Other Eukaryotes - 2160 (source: NCBI BLink).
NP_196217.2
  • DHFS-FPGS homolog B (DFB); CONTAINS InterPro DOMAIN/s: Folylpolyglutamate synthetase, conserved site (InterPro:IPR018109), Mur ligase, central (InterPro:IPR013221), Mur ligase, C-terminal (InterPro:IPR004101), Folylpolyglutamate synthetase (InterPro:IPR001645); BEST Arabidopsis thaliana protein match is: DHFS-FPGS homolog D (TAIR:AT3G55630.3); Has 7626 Blast hits to 7624 proteins in 2505 species: Archae - 43; Bacteria - 4775; Metazoa - 165; Fungi - 350; Plants - 132; Viruses - 0; Other Eukaryotes - 2161 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1799490..1804492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120680.3 → NP_196217.2  DHFS-FPGS homolog B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196217.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DH96, F4K2A1, F4K2A2, Q8W040, Q9FI88
    UniProtKB/TrEMBL
    A0A178URZ6
    Conserved Domains (1) summary
    PLN02881
    Location:54 → 571
    PLN02881; tetrahydrofolylpolyglutamate synthase

  2. NM_001036763.2 → NP_001031840.1  DHFS-FPGS homolog B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9Y247
    Conserved Domains (1) summary
    PLN02881
    Location:1 → 513
    PLN02881; tetrahydrofolylpolyglutamate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4K2A1.1

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