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CD99L2 CD99 molecule like 2 [ Homo sapiens (human) ]

Gene ID: 83692, updated on 10-Dec-2024

Summary

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Official Symbol
CD99L2provided by HGNC
Official Full Name
CD99 molecule like 2provided by HGNC
Primary source
HGNC:HGNC:18237
See related
Ensembl:ENSG00000102181 MIM:300846; AllianceGenome:HGNC:18237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD99B; MIC2L1
Summary
This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in brain (RPKM 33.3), fat (RPKM 18.8) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD99L2 in Genome Data Viewer
Location:
Xq28
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (150766336..150898668, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (149033979..149166303, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (149934809..150067141, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:149733744-149734666 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:149734667-149735588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30022 Neighboring gene myotubularin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30024 Neighboring gene myotubularin related protein 1 Neighboring gene cytochrome P450 family 2 subfamily C member 64, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:149940339-149940886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:149940887-149941432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:149946045-149946676 Neighboring gene uncharacterized LOC124905294 Neighboring gene peptidylprolyl isomerase A pseudogene 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30025 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:150058782-150059282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:150059283-150059783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21054 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:150070302-150070988 Neighboring gene uncharacterized LOC124905297 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:150070989-150071673 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:150071674-150072359 Neighboring gene long intergenic non-protein coding RNA 2927

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Human CD99L2 Regulates a Unique Step in Leukocyte Transmigration. Rutledge NS, et al. J Immunol, 2022 Sep 1. PMID 35914838, Free PMC Article
  2. The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response. Schenkel AR, et al. Cell Commun Adhes, 2007 Sep-Oct. PMID 18163232
  3. Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces. Nam G, et al. J Immunol, 2013 Dec 1. PMID 24133166, Free PMC Article
  4. Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy. McMichael G, et al. Mol Psychiatry, 2015 Feb. PMID 25666757
  5. Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. Suh YH, et al. Gene, 2003 Mar 27. PMID 12706889

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human CD99L2 Regulates a Unique Step in Leukocyte Transmigration.
    Title: Human CD99L2 Regulates a Unique Step in Leukocyte Transmigration.
  2. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes CD99L2.
    Title: Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD99L2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761H2024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in diapedesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell extravasation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neutrophil extravasation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD99 antigen-like protein 2
Names
MIC2 like 1
MIC2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021320.2 RefSeqGene

    Range
    5149..137481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184808.2 → NP_001171737.1  CD99 antigen-like protein 2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three consecutive in-frame exons in one region and an in-frame exon in another region, compared to variant 5. The resulting isoform (4) lacks two internal segments, compared to isoform 5.
    Source sequence(s)
    AF002223, AK293244, BC025729, DC323066
    Consensus CDS
    CCDS55527.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000394858.2, ENST00000437787.6
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 166
    CD99L2; CD99 antigen like protein 2

  2. NM_001242614.2 → NP_001229543.1  CD99 antigen-like protein 2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AK125020, AY358837, BC030536, DC323066
    Consensus CDS
    CCDS76044.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 249
    CD99L2; CD99 antigen like protein 2

  3. NM_031462.4 → NP_113650.2  CD99 antigen-like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_113650.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the 3' region, compared to variant 5. The resulting isoform (1, also referred to as E3'-E4'-E3-E4) lacks an internal segment, compared to isoform 5.
    Source sequence(s)
    BC025729, BC030536
    Consensus CDS
    CCDS35427.1
    UniProtKB/Swiss-Prot
    A8K2D5, A8K5R0, B3KWG2, B4DDL7, E7EMK5, E9PD27, Q8TAW2, Q8TCZ0, Q8TCZ1, Q8TCZ2, Q9BQG9
    UniProtKB/TrEMBL
    A0A024RC16
    Related
    ENSP00000359403.3, ENST00000370377.8
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 239
    CD99L2; CD99 antigen like protein 2

  4. NM_134445.4 → NP_604394.1  CD99 antigen-like protein 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_604394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three consecutive in-frame exons in one region and an in-frame exon in another region, compared to variant 5. The resulting isoform (3, also referred to as E4) lacks two internal segments, compared to isoform 5.
    Source sequence(s)
    AY078167, BC025729, DC323066
    Consensus CDS
    CCDS14697.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000347275.3, ENST00000355149.8
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 167
    CD99L2; CD99 antigen like protein 2

  5. NM_134446.4 → NP_604395.1  CD99 antigen-like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_604395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive in-frame exons in one region and an in-frame exon in another region, compared to variant 5. The resulting isoform (2, also referred to as E3-E4) lacks two internal segments, compared to isoform 5.
    Source sequence(s)
    AY078166, BC025729, DC323066
    Consensus CDS
    CCDS14698.1
    UniProtKB/Swiss-Prot
    Q8TCZ2
    Related
    ENSP00000417697.1, ENST00000466436.5
    Conserved Domains (1) summary
    pfam12301
    Location:30 → 190
    CD99L2; CD99 antigen like protein 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    150766336..150898668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442560.1 → XP_047298516.1  CD99 antigen-like protein 2 isoform X1

  2. XM_047442562.1 → XP_047298518.1  CD99 antigen-like protein 2 isoform X1

  3. XM_047442561.1 → XP_047298517.1  CD99 antigen-like protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    149033979..149166303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327951.1 → XP_054183926.1  CD99 antigen-like protein 2 isoform X1

  2. XM_054327953.1 → XP_054183928.1  CD99 antigen-like protein 2 isoform X1

  3. XM_054327952.1 → XP_054183927.1  CD99 antigen-like protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCZ2.1 GenPept UniProtKB/Swiss-Prot:Q8TCZ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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