NDA1 alternative NAD(P)H dehydrogenase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: NDA1
Official Full Name: alternative NAD(P)H dehydrogenase 1
Primary source: TAIR:AT1G07180
Locus tag: AT1G07180
See related: Araport:AT1G07180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: alternative NAD(P)H dehydrogenase 1; alternative NAD(P)H dehydrogenase 1; ARABIDOPSIS THALIANA INTERNAL NON-PHOSPHORYLATING NAD ( P ) H DEHYDROGENASE; ATNDI1; F10K1.11; F10K1_11; NADH-DEHYDROGENASE
Summary: Internal NAD(P)H dehydrogenase in mitochondria. The predicted protein sequence has high homology with other designated NAD(P)H DHs from microorganisms; the capacity for matrix NAD(P)H oxidation via the rotenone-insensitive pathway is significantly reduced in the Atndi1 mutant plant line; the in vitro translation product of AtNDI1 is imported into isolated mitochondria and located on the inside of the inner membrane.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.
Title: Mitochondrial alternative NADH dehydrogenases NDA1 and NDA2 promote survival of reoxygenation stress in Arabidopsis by safeguarding photosynthesis and limiting ROS generation.
Data indicate that suppressing the type II NAD(P)H dehydrogenase genes NDA1 (BT005564.1) and NDA2. (NM_128553.2) substantially reduced levels of both proteins in leaf mitochondria.
Title: Suppression of NDA-type alternative mitochondrial NAD(P)H dehydrogenases in arabidopsis thaliana modifies growth and metabolism, but not high light stimulation of mitochondrial electron transport.

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NM_100592.5

Function	Evidence Code	Pubs
enables NADH dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NADPH dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_563783.1

alternative NAD(P)H dehydrogenase 1 (NDA1); FUNCTIONS IN: NADH dehydrogenase activity; INVOLVED IN: oxidation reduction; LOCATED IN: intrinsic to mitochondrial inner membrane, mitochondrion; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: alternative NAD(P)H dehydrogenase 2 (TAIR:AT2G29990.1); Has 9792 Blast hits to 9601 proteins in 2135 species: Archae - 248; Bacteria - 7524; Metazoa - 53; Fungi - 647; Plants - 379; Viruses - 0; Other Eukaryotes - 941 (source: NCBI BLink).

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