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nr5a1a nuclear receptor subfamily 5, group A, member 1a [ Danio rerio (zebrafish) ]

Gene ID: 83916, updated on 14-Nov-2024

Summary

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Official Symbol
nr5a1aprovided by ZNC
Official Full Name
nuclear receptor subfamily 5, group A, member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010504-1
See related
Ensembl:ENSDARG00000103176 AllianceGenome:ZFIN:ZDB-GENE-010504-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ff1b; SF1-A; nr5a4
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including endocrine system development; hypothalamus development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in endocrine system; forebrain; gonad primordium; and interrenal primordium. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See nr5a1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (52833443..52861402, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (52847150..52873008, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 17 Neighboring gene adhesion G protein-coupled receptor D2 Neighboring gene nuclear receptor subfamily 6, group A, member 1a Neighboring gene uncharacterized LOC110440026 Neighboring gene microRNA 181a-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish. Sun L, et al. Toxicol Appl Pharmacol, 2010 Nov 1. PMID 20732339
  2. The hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryo. Chou CW, et al. PLoS One, 2014. PMID 25248158, Free PMC Article
  3. Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Hsu HJ, et al. Endocr Res, 2004 Nov. PMID 15666828
  4. Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b. Quek SI, et al. J Mol Endocrinol, 2009 Sep. PMID 19477906
  5. Molecular Mechanisms of Podocyte Development Revealed by Zebrafish Kidney Research. Miceli R, et al. Cell Dev Biol, 2014. PMID 25485314, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs.
    Title: A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs.
  2. Interruption of ff1b expression using an ff1b-morpholino (MO) disrupts development of insulin expressing cells.
    Title: ff1b, the SF1 ortholog, is important for pancreatic islet cell development in zebrafish.
  3. The putative promoter of zebrafish cyp11a1, spanning 1.7 kb, was isolated and bioinformatic analysis revealed two conserved FF1 response elements (FREs) that potentially bind Ff1b.
    Title: Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b.
  4. Ff1b is regulated by prox1 in zebrafish
    Title: Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.
  5. Required for interrenal differentiation and activation of the differentiated gene cyp11a1.
    Title: Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b.
  6. Ff1b is required for the development of the steroidogenic component of the zebrafish interrenal organ.
    Title: Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ.
  7. The cloning and expression of 4 homologous genes in D. rerio are reported.
    Title: Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hypothalamus development IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
steroidogenic factor 1a
Names
nuclear receptor subfamily 5, group A, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131794.1 → NP_571869.1  steroidogenic factor 1a

    See identical proteins and their annotated locations for NP_571869.1

    Status: PROVISIONAL

    Source sequence(s)
    AF198086
    UniProtKB/TrEMBL
    Q9IAI9
    Related
    ENSDARP00000130433.1, ENSDART00000162004.2
    Conserved Domains (2) summary
    cd06944
    Location:212 → 449
    NR_LBD_Ftz-F1_like; The ligand binding domain of FTZ-F1 like nuclear receptors
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    52833443..52861402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478333.2 → XP_021334008.1  steroidogenic factor 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q3M8, F1QJG0
    Related
    ENSDARP00000140514.1, ENSDART00000170179.2
    Conserved Domains (2) summary
    cd06944
    Location:212 → 449
    NR_LBD_Ftz-F1_like; The ligand binding domain of FTZ-F1 like nuclear receptors
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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