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SGIP1 SH3GL interacting endocytic adaptor 1 [ Homo sapiens (human) ]

Gene ID: 84251, updated on 3-Nov-2024

Summary

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Official Symbol
SGIP1provided by HGNC
Official Full Name
SH3GL interacting endocytic adaptor 1provided by HGNC
Primary source
HGNC:HGNC:25412
See related
Ensembl:ENSG00000118473 MIM:611540; AllianceGenome:HGNC:25412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 8.0), endometrium (RPKM 2.4) and 11 other tissues See more
Orthologs
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Genomic context

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See SGIP1 in Genome Data Viewer
Location:
1p31.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (66533361..66751139)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (66410946..66628673)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (66999044..67216822)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4B Neighboring gene RNA, U4 small nuclear 88, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:66694092-66694275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1152 Neighboring gene Sharpr-MPRA regulatory region 6178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1155 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:66820269-66820769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1160 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:66866019-66867218 Neighboring gene uncharacterized LOC105378776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946325-66946955 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946956-66947585 Neighboring gene uncharacterized LOC124904196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1166 Neighboring gene microRNA 3117 Neighboring gene dynein light chain Tctex-type family member 5 Neighboring gene insulin like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma. Xie GF, et al. Neoplasma, 2021 Jan. PMID 33118832
  2. SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis. Zhang Y, et al. Biochem Biophys Res Commun, 2018 Oct 20. PMID 30236986
  3. Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage. Chwedorowicz R, et al. Ann Agric Environ Med, 2016 Dec 23. PMID 28030933
  4. Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power. Derringer J, et al. Psychiatr Genet, 2011 Oct. PMID 21317682, Free PMC Article
  5. Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass. Cummings N, et al. Int J Obes (Lond), 2012 Feb. PMID 21407171

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
    Title: Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
  2. Data indicate that cysteine C632 residue is important for the function of SH3 domain GRB2 like endophilin interacting protein 1 (SGIP1) during cellular endocytosis.
    Title: SGIP1 dimerizes via intermolecular disulfide bond in μHD domain during cellular endocytosis.
  3. The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
    Title: Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage.
  4. crystal structures of the SGIP1 mu homology domains in complex with peptides containing two DPF motifs, are reported.
    Title: Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain.
  5. Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans
    Title: Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass.
  6. The earlier implicated single nucleotide polymorphisms located in SGIP1 gene showed no association with alcohol dependence or theta electroencephalogram power.
    Title: Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
  7. SGIP1 and the signaling adaptor Reps1 interact with ITSN1 in vivo.
    Title: Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.
  8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association identifies candidate genes that influence the human electroencephalogram.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of early menopause and the combined impact of identified variants.
EBI GWAS Catalog
Genome-wide association study of antiphospholipid antibodies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ33378, FLJ43054, DKFZp761D221, DKFZp686A16142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to dietary excess ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3-containing GRB2-like protein 3-interacting protein 1
Names
SH3 domain GRB2 like endophilin interacting protein 1
endophilin-3-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308203.2 → NP_001295132.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001295132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which has the same N- and C-termini, but has some distinct internal segments, is lacking other internal segments, and is shorter than isoform 1.
    Source sequence(s)
    AL136561, AL354978, AW205180, BC040516, BX640813
    Consensus CDS
    CCDS76171.1
    UniProtKB/TrEMBL
    A0A804HJI3
    Related
    ENSP00000360078.1, ENST00000371039.5
    Conserved Domains (1) summary
    cd09266
    Location:364 → 630
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  2. NM_001350217.2 → NP_001337146.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, but also lacks an alternate exon in the 5' coding region, compared to variant 1. This variant encodes isoform 3, which has the same N- and C-termini, but is four aa longer than isoform 1.
    Source sequence(s)
    AB210039, AL136561, AL354978, AW205180, BC040516, DA491011
    UniProtKB/TrEMBL
    A0A804HJS7
    Related
    ENSP00000237247.6, ENST00000237247.10
    Conserved Domains (1) summary
    cd09266
    Location:565 → 831
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  3. NM_001350218.2 → NP_001337147.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. This variant encodes isoform 4, which has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AK299941, AL136561, AL354978, AW205180
    UniProtKB/TrEMBL
    B7Z5H8, B7Z691
    Conserved Domains (1) summary
    cd09266
    Location:370 → 636
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  4. NM_001376534.1 → NP_001363463.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS30744.1
    UniProtKB/Swiss-Prot
    A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5
    UniProtKB/TrEMBL
    A0A804HHZ7
    Conserved Domains (1) summary
    cd09266
    Location:561 → 827
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  5. NM_001376535.1 → NP_001363464.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS30744.1
    UniProtKB/Swiss-Prot
    A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5
    UniProtKB/TrEMBL
    A0A804HHZ7
    Conserved Domains (1) summary
    cd09266
    Location:561 → 827
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  6. NM_001376536.1 → NP_001363465.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS76171.1
    UniProtKB/TrEMBL
    A0A804HJI3
    Related
    ENSP00000508234.1, ENST00000684664.1
    Conserved Domains (1) summary
    cd09266
    Location:364 → 630
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  7. NM_001376537.1 → NP_001363466.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJJ5
    Conserved Domains (1) summary
    cd09266
    Location:559 → 825
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  8. NM_001376538.1 → NP_001363467.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJS7
    Conserved Domains (1) summary
    cd09266
    Location:545 → 811
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  9. NM_001376539.1 → NP_001363468.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HHZ7
    Conserved Domains (1) summary
    cd09266
    Location:541 → 807
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  10. NM_001376540.1 → NP_001363469.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HHZ7
    Conserved Domains (1) summary
    cd09266
    Location:541 → 807
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  11. NM_001376541.1 → NP_001363470.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJJ5
    Conserved Domains (1) summary
    cd09266
    Location:537 → 803
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  12. NM_001376542.1 → NP_001363471.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJJ5
    Conserved Domains (1) summary
    cd09266
    Location:537 → 803
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  13. NM_001376543.1 → NP_001363472.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJJ5
    Conserved Domains (1) summary
    cd09266
    Location:537 → 803
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  14. NM_001376544.1 → NP_001363473.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJJ5
    Conserved Domains (1) summary
    cd09266
    Location:517 → 783
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  15. NM_001376545.1 → NP_001363474.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    A0A804HJJ5
    Conserved Domains (1) summary
    cd09266
    Location:517 → 783
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  16. NM_001376546.1 → NP_001363475.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    UniProtKB/TrEMBL
    B7Z5H8
    Conserved Domains (1) summary
    cd09266
    Location:398 → 664
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  17. NM_001376547.1 → NP_001363476.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90969.1
    UniProtKB/TrEMBL
    A0A804HJG4, A0A804HJI3
    Related
    ENSP00000507495.1, ENST00000684168.1
    Conserved Domains (1) summary
    cd09266
    Location:388 → 654
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  18. NM_001376548.1 → NP_001363477.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90970.1
    UniProtKB/TrEMBL
    A0A804HHV6, A0A804HJI3
    Related
    ENSP00000507159.1, ENST00000684178.1
    Conserved Domains (1) summary
    cd09266
    Location:386 → 652
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  19. NM_001376549.1 → NP_001363478.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90970.1
    UniProtKB/TrEMBL
    A0A804HHV6, A0A804HJI3
    Related
    ENSP00000506779.1, ENST00000682707.1
    Conserved Domains (1) summary
    cd09266
    Location:386 → 652
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  20. NM_001376550.1 → NP_001363479.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90971.1
    UniProtKB/TrEMBL
    A0A804HJI3, A0A804HJX5
    Related
    ENSP00000507684.1, ENST00000681971.1
    Conserved Domains (1) summary
    cd09266
    Location:366 → 632
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  21. NM_001376551.1 → NP_001363480.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90972.1
    UniProtKB/TrEMBL
    B7Z5H8
    Related
    ENSP00000507311.1, ENST00000684539.1
    Conserved Domains (1) summary
    cd09266
    Location:362 → 628
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  22. NM_001376552.1 → NP_001363481.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90972.1
    UniProtKB/TrEMBL
    B7Z5H8
    Related
    ENSP00000507967.1, ENST00000683257.1
    Conserved Domains (1) summary
    cd09266
    Location:362 → 628
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  23. NM_001376554.1 → NP_001363483.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90973.1
    UniProtKB/TrEMBL
    A0A804HI01, B7Z5H8
    Related
    ENSP00000395525.3, ENST00000435165.3
    Conserved Domains (1) summary
    cd09266
    Location:342 → 608
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  24. NM_001376555.1 → NP_001363484.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL354978, AL356913
    Consensus CDS
    CCDS90973.1
    UniProtKB/TrEMBL
    A0A804HI01, B7Z5H8
    Related
    ENSP00000506836.1, ENST00000682293.1
    Conserved Domains (1) summary
    cd09266
    Location:342 → 608
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  25. NM_001376556.1 → NP_001363485.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL356913
    UniProtKB/TrEMBL
    A0A804HIX4
    Related
    ENSP00000506802.1, ENST00000684083.1

  26. NM_001376557.1 → NP_001363486.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL139147, AL356913
    UniProtKB/TrEMBL
    A0A804HJ90
    Related
    ENSP00000410439.2, ENST00000424320.6

  27. NM_032291.4 → NP_115667.2  SH3-containing GRB2-like protein 3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_115667.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL136561, AL354978, AW205180, BC040516, DA491011
    Consensus CDS
    CCDS30744.1
    UniProtKB/Swiss-Prot
    A6NL81, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2, Q9BQI5
    UniProtKB/TrEMBL
    A0A804HHZ7
    Related
    ENSP00000360076.3, ENST00000371037.9
    Conserved Domains (1) summary
    cd09266
    Location:561 → 827
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    66533361..66751139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432059.1 → XP_047288015.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HJX5

  2. XM_047432054.1 → XP_047288010.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A804HHV6

  3. XM_047432058.1 → XP_047288014.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HJX5

  4. XM_005271270.5 → XP_005271327.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

    See identical proteins and their annotated locations for XP_005271327.1

    UniProtKB/TrEMBL
    B7Z5H8
    Conserved Domains (1) summary
    cd09266
    Location:362 → 628
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  5. XM_017002506.2 → XP_016857995.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A804HHZ7

  6. XM_017002510.2 → XP_016857999.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A804HHZ7

  7. XM_017002524.2 → XP_016858013.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A804HJI3
    Conserved Domains (1) summary
    cd09266
    Location:408 → 674
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  8. XM_047432055.1 → XP_047288011.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A804HHV6

  9. XM_017002508.2 → XP_016857997.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A804HHZ7

  10. XM_047432052.1 → XP_047288008.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

    Related
    ENSP00000506830.1, ENST00000683499.1

  11. XM_047432051.1 → XP_047288007.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

  12. XM_017002516.2 → XP_016858005.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A804HJJ5
    Related
    ENSP00000508116.1, ENST00000682054.1
    Conserved Domains (1) summary
    cd09266
    Location:551 → 817
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  13. XM_017002528.2 → XP_016858017.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

    UniProtKB/TrEMBL
    B7Z5H8

  14. XM_047432061.1 → XP_047288017.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

    Related
    ENSP00000507400.1, ENST00000683291.1

  15. XM_006710961.3 → XP_006711024.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006711024.1

    UniProtKB/TrEMBL
    A0A804HJS7
    Conserved Domains (1) summary
    cd09266
    Location:567 → 833
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  16. XM_006710971.3 → XP_006711034.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

    See identical proteins and their annotated locations for XP_006711034.1

    UniProtKB/TrEMBL
    A0A804HJI3
    Conserved Domains (1) summary
    cd09266
    Location:400 → 666
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  17. XM_017002529.2 → XP_016858018.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A804HJI3

  18. XM_006710973.3 → XP_006711036.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

    See identical proteins and their annotated locations for XP_006711036.1

    UniProtKB/TrEMBL
    A0A804HJI3
    Conserved Domains (1) summary
    cd09266
    Location:392 → 658
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  19. XM_047432053.1 → XP_047288009.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

  20. XM_047432057.1 → XP_047288013.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

  21. XM_017002505.2 → XP_016857994.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A804HHZ7

  22. XM_017002507.2 → XP_016857996.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A804HHZ7

  23. XM_011542291.2 → XP_011540593.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

    See identical proteins and their annotated locations for XP_011540593.1

    UniProtKB/TrEMBL
    A0A804HJI3
    Conserved Domains (1) summary
    cd09266
    Location:393 → 659
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  24. XM_011542292.2 → XP_011540594.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

    See identical proteins and their annotated locations for XP_011540594.1

    UniProtKB/TrEMBL
    A0A804HJI3
    Conserved Domains (1) summary
    cd09266
    Location:373 → 639
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

  25. XM_047432056.1 → XP_047288012.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

  26. XM_047432060.1 → XP_047288016.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

  27. XM_017002515.2 → XP_016858004.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A804HJJ5
    Related
    ENSP00000507528.1, ENST00000683581.1
    Conserved Domains (1) summary
    cd09266
    Location:551 → 817
    SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

RNA

  1. XR_007064415.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    66410946..66628673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339159.1 → XP_054195134.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HJX5

  2. XM_054339152.1 → XP_054195127.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A804HHV6

  3. XM_054339162.1 → XP_054195137.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X21

  4. XM_054339138.1 → XP_054195113.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

  5. XM_054339141.1 → XP_054195116.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

  6. XM_054339147.1 → XP_054195122.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

  7. XM_054339153.1 → XP_054195128.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A804HHV6

  8. XM_054339140.1 → XP_054195115.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

  9. XM_054339144.1 → XP_054195119.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

  10. XM_054339143.1 → XP_054195118.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

  11. XM_054339146.1 → XP_054195121.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

  12. XM_054339155.1 → XP_054195130.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

  13. XM_054339163.1 → XP_054195138.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X22

  14. XM_054339160.1 → XP_054195135.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HJX5

  15. XM_054339142.1 → XP_054195117.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

  16. XM_054339148.1 → XP_054195123.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

  17. XM_054339156.1 → XP_054195131.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X16

  18. XM_054339150.1 → XP_054195125.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

  19. XM_054339151.1 → XP_054195126.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

  20. XM_054339158.1 → XP_054195133.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X18

  21. XM_054339137.1 → XP_054195112.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

  22. XM_054339139.1 → XP_054195114.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

  23. XM_054339149.1 → XP_054195124.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

  24. XM_054339157.1 → XP_054195132.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X17

  25. XM_054339154.1 → XP_054195129.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

  26. XM_054339161.1 → XP_054195136.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X20

  27. XM_054339145.1 → XP_054195120.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

RNA

  1. XR_008486178.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BQI5.2 GenPept UniProtKB/Swiss-Prot:Q9BQI5

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