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FLYWCH1 FLYWCH-type zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 84256, updated on 10-Dec-2024

Summary

Official Symbol
FLYWCH1provided by HGNC
Official Full Name
FLYWCH-type zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:25404
See related
Ensembl:ENSG00000059122 MIM:620431; AllianceGenome:HGNC:25404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables transcription coactivator binding activity and transcription corepressor activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and pericentric heterochromatin. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in spleen (RPKM 6.6), ovary (RPKM 5.2) and 25 other tissues See more
Orthologs
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Genomic context

See FLYWCH1 in Genome Data Viewer
Location:
16p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2911931..2951208)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2938537..2977878)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2961932..3001209)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene FLYWCH family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:2955125-2955625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7084 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2962376-2962565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2974631-2975496 Neighboring gene ribosomal protein L23a pseudogene 86 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:2978151-2978660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2988192-2988805 Neighboring gene uncharacterized LOC105371055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3005307-3006228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3006229-3007148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3011513-3012510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3012511-3013508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3015093-3016052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3018331-3019320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3021603-3022419 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
FLYWCH-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308068.2NP_001294997.1  FLYWCH-type zinc finger-containing protein 1 isoform c

    See identical proteins and their annotated locations for NP_001294997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is longer than isoform a.
    Source sequence(s)
    AC004034, AC004234, AC004235
    Consensus CDS
    CCDS76809.1
    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    Related
    ENSP00000253928.9, ENST00000253928.14
    Conserved Domains (3) summary
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332393
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    pfam04500
    Location:421479
    FLYWCH; FLYWCH zinc finger domain
  2. NM_020912.2NP_065963.1  FLYWCH-type zinc finger-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AC004034, AC004234
    UniProtKB/Swiss-Prot
    Q4VC44
    Conserved Domains (3) summary
    pfam04500
    Location:272330
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:331419
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  3. NM_032296.3NP_115672.2  FLYWCH-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_115672.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AC004034, AC004234, AC004235
    Consensus CDS
    CCDS45390.1
    UniProtKB/Swiss-Prot
    Q4VC44
    Related
    ENSP00000399938.2, ENST00000416288.6
    Conserved Domains (3) summary
    pfam04500
    Location:272330
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:331419
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2911931..2951208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434780.1XP_047290736.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    Conserved Domains (3) summary
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332393
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    pfam04500
    Location:421479
    FLYWCH; FLYWCH zinc finger domain
  2. XM_047434784.1XP_047290740.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

  3. XM_047434776.1XP_047290732.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

  4. XM_011522703.3XP_011521005.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521005.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  5. XM_047434779.1XP_047290735.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    Conserved Domains (3) summary
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332393
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    pfam04500
    Location:421479
    FLYWCH; FLYWCH zinc finger domain
  6. XM_047434783.1XP_047290739.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

  7. XM_006720962.4XP_006721025.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006721025.1

    UniProtKB/Swiss-Prot
    Q4VC44
    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  8. XM_011522701.3XP_011521003.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521003.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  9. XM_011522705.3XP_011521007.1  FLYWCH-type zinc finger-containing protein 1 isoform X4

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  10. XM_047434777.1XP_047290733.1  FLYWCH-type zinc finger-containing protein 1 isoform X7

  11. XM_011522704.3XP_011521006.1  FLYWCH-type zinc finger-containing protein 1 isoform X2

    Conserved Domains (3) summary
    pfam04500
    Location:272330
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:331419
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  12. XM_047434774.1XP_047290730.1  FLYWCH-type zinc finger-containing protein 1 isoform X3

  13. XM_047434785.1XP_047290741.1  FLYWCH-type zinc finger-containing protein 1 isoform X10

  14. XM_047434786.1XP_047290742.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

  15. XM_047434789.1XP_047290745.1  FLYWCH-type zinc finger-containing protein 1 isoform X14

  16. XM_011522707.3XP_011521009.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

    See identical proteins and their annotated locations for XP_011521009.1

    Conserved Domains (3) summary
    pfam04500
    Location:273331
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332420
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
  17. XM_047434787.1XP_047290743.1  FLYWCH-type zinc finger-containing protein 1 isoform X12

  18. XM_047434775.1XP_047290731.1  FLYWCH-type zinc finger-containing protein 1 isoform X5

  19. XM_047434782.1XP_047290738.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

  20. XM_047434781.1XP_047290737.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    Conserved Domains (3) summary
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332393
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    pfam04500
    Location:421479
    FLYWCH; FLYWCH zinc finger domain
  21. XM_047434778.1XP_047290734.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
    Conserved Domains (3) summary
    pfam15423
    Location:1107
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:332393
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
    pfam04500
    Location:421479
    FLYWCH; FLYWCH zinc finger domain
  22. XM_047434788.1XP_047290744.1  FLYWCH-type zinc finger-containing protein 1 isoform X13

  23. XM_047434790.1XP_047290746.1  FLYWCH-type zinc finger-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    B3KP60
  24. XM_047434791.1XP_047290747.1  FLYWCH-type zinc finger-containing protein 1 isoform X16

    UniProtKB/TrEMBL
    B3KP60

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2938537..2977878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314171.1XP_054170146.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
  2. XM_054314175.1XP_054170150.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

  3. XM_054314167.1XP_054170142.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

  4. XM_054314160.1XP_054170135.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

  5. XM_054314170.1XP_054170145.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
  6. XM_054314174.1XP_054170149.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

  7. XM_054314166.1XP_054170141.1  FLYWCH-type zinc finger-containing protein 1 isoform X6

  8. XM_054314159.1XP_054170134.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

  9. XM_054314163.1XP_054170138.1  FLYWCH-type zinc finger-containing protein 1 isoform X17

  10. XM_054314164.1XP_054170139.1  FLYWCH-type zinc finger-containing protein 1 isoform X4

  11. XM_054314168.1XP_054170143.1  FLYWCH-type zinc finger-containing protein 1 isoform X7

  12. XM_054314161.1XP_054170136.1  FLYWCH-type zinc finger-containing protein 1 isoform X2

  13. XM_054314162.1XP_054170137.1  FLYWCH-type zinc finger-containing protein 1 isoform X3

  14. XM_054314176.1XP_054170151.1  FLYWCH-type zinc finger-containing protein 1 isoform X10

  15. XM_054314177.1XP_054170152.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

  16. XM_054314181.1XP_054170156.1  FLYWCH-type zinc finger-containing protein 1 isoform X14

  17. XM_054314178.1XP_054170153.1  FLYWCH-type zinc finger-containing protein 1 isoform X11

  18. XM_054314180.1XP_054170155.1  FLYWCH-type zinc finger-containing protein 1 isoform X12

  19. XM_054314165.1XP_054170140.1  FLYWCH-type zinc finger-containing protein 1 isoform X5

  20. XM_054314173.1XP_054170148.1  FLYWCH-type zinc finger-containing protein 1 isoform X9

  21. XM_054314172.1XP_054170147.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
  22. XM_054314169.1XP_054170144.1  FLYWCH-type zinc finger-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    D3DUA1, Q4VC44, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
  23. XM_054314179.1XP_054170154.1  FLYWCH-type zinc finger-containing protein 1 isoform X13