YIPF4 Yip1 domain family member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: YIPF4provided by HGNC
Official Full Name: Yip1 domain family member 4provided by HGNC
Primary source: HGNC:HGNC:28145
See related: Ensembl:ENSG00000119820 MIM:617534; AllianceGenome:HGNC:28145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FinGER4; Nbla11189; YIPFalpha2
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thyroid (RPKM 14.7), fat (RPKM 12.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p22.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (32277904..32316594)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (32326427..32365131)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (32502973..32541663)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The significance of YIPF4 protein for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion.
Title: Functional characterisation of the YIPF protein family in mammalian cells.
YIPF4 is a binding partner of the papillomavirus E5 proteins.
Title: YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins.
YIPF4 was detected as a single mobility form consistent with its predicted molecular weight, three different mobility forms of YIPF3 were detected by western blotting.
Title: Characterization of YIPF3 and YIPF4, cis-Golgi Localizing Yip domain family proteins.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-11827 (e-PCR)
- UniSTS:83468

RH11547 (e-PCR)
- UniSTS:42794

D2S1497E (e-PCR)
- UniSTS:150340

RH46370 (e-PCR)
- UniSTS:9635

SHGC-56786 (e-PCR)
- UniSTS:66014

SHGC-56665 (e-PCR)
- UniSTS:21227

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein YIPF4

Names: YIP1 family member 4; putative protein product of Nbla11189

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032312.4 → NP_115688.1 protein YIPF4

See identical proteins and their annotated locations for NP_115688.1

Status: VALIDATED

Source sequence(s)

AL121653, AL133245, BC004875, BP207600, BU608699

Consensus CDS

CCDS1781.1

UniProtKB/Swiss-Prot

Q9BSR8

Related

ENSP00000238831.3, ENST00000238831.9

Conserved Domains (1) summary

cl21557
Location:74 → 237

Yip1; Yip1 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

32277904..32316594

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005264599.4 → XP_005264656.1 protein YIPF4 isoform X1

Conserved Domains (1) summary

cl21557
Location:74 → 200

Yip1; Yip1 domain
XM_024453173.2 → XP_024308941.1 protein YIPF4 isoform X2

Conserved Domains (1) summary

cl21557
Location:74 → 174

Yip1; Yip1 domain