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ING5 inhibitor of growth family member 5 [ Homo sapiens (human) ]

Gene ID: 84289, updated on 10-Dec-2024

Summary

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Official Symbol
ING5provided by HGNC
Official Full Name
inhibitor of growth family member 5provided by HGNC
Primary source
HGNC:HGNC:19421
See related
Ensembl:ENSG00000168395 MIM:608525; AllianceGenome:HGNC:19421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p28ING5
Summary
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ING5 in Genome Data Viewer
Location:
2q37.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241687020..241729478)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (242190352..242233501)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242626435..242668893)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242576729-242577656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242578056-242578589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242584167-242584667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242584739-242585240 Neighboring gene autophagy related 4B cysteine peptidase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242596891-242597666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242600039-242600540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242600541-242601040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242604899-242605504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242607599-242608100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242608101-242608600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12553 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242626177-242626439 Neighboring gene deoxythymidylate kinase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242640872-242641704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242641943-242642572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17431 Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene MPRA-validated peak4107 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242703699-242704312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242710178-242711090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242714429-242715049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242716291-242716911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242716912-242717532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242717533-242718152 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:242727152-242728351 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene CEB1 minisatellite repeat instability region

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer. Zhang F, et al. Oncotarget, 2015 Jun 30. PMID 25938545, Free PMC Article
  2. [Nucleocytoplasmic translocation of ING5 protein in breast cancer and its correlation with poor clinicopathological characteristics of breast cancer]. Song Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2018 Jan. PMID 29595458
  3. Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma. Cengiz B, et al. Int J Cancer, 2010 Nov 1. PMID 20131318
  4. ING5 is a Potential Target for Osteosarcoma Therapy. Zhang X, et al. Technol Cancer Res Treat, 2018 Jan 1. PMID 29528777, Free PMC Article
  5. Overexpression of ING5 inhibits HGF-induced proliferation, invasion and EMT in thyroid cancer cells via regulation of the c-Met/PI3K/Akt signaling pathway. Gao W, et al. Biomed Pharmacother, 2018 Feb. PMID 29272787

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
    Title: ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
  2. Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
    Title: Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
  3. ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
    Title: ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
  4. MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
    Title: MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
  5. LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
    Title: LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
  6. The data suggest that miR-376c-3p downregulated ING5 to exert protective effects against oxygen-glucose deprivation-induced cell injury in cultured human and rat cells.
    Title: Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.
  7. ING5 forms homodimers through its N-terminal domain, which folds independently into an elongated coiled-coil structure.
    Title: The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
  8. Results show that ING5 overexpression promotes phosphorylation-dependent degradation of beta-catenin, leading to downregulated Wnt/beta- catenin signaling and inhibition of lung cancer invasion and epithelial-mesenchymal transition.
    Title: ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway.
  9. The Hepatitis B virus X protein (HBx) downregulates the expression of the miR-181b target gene ING5, resulting in the promotion of HCC cell proliferation.
    Title: Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5.
  10. our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis
    Title: ING5 is a Potential Target for Osteosarcoma Therapy.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23842, AC133528.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of growth IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 5

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330161.2 → NP_001317090.1  inhibitor of growth protein 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate promoter and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC114730, AC133528
    Consensus CDS
    CCDS82585.1
    UniProtKB/TrEMBL
    A0A1B0GW41
    Related
    ENSP00000490767.1, ENST00000636051.1

  2. NM_001330162.2 → NP_001317091.1  inhibitor of growth protein 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' terminal exon compared to variant 1. The encoded isoform (3) has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AC114730, AC133528, BC005370
    Consensus CDS
    CCDS82586.1
    UniProtKB/Swiss-Prot
    Q8WYH8
    Related
    ENSP00000385937.1, ENST00000406941.5
    Conserved Domains (2) summary
    cd15586
    Location:188 → 226
    PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
    cd16863
    Location:12 → 104
    ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

  3. NM_032329.6 → NP_115705.2  inhibitor of growth protein 5 isoform 1

    See identical proteins and their annotated locations for NP_115705.2

    Status: REVIEWED

    Source sequence(s)
    AC133528, AF189286, AI701412, AK074422, AK128322, BC039028, BI962551, BQ187350
    Consensus CDS
    CCDS33425.1
    UniProtKB/Swiss-Prot
    A8K1P3, Q53NU6, Q57Z54, Q8WYH8, Q9BS30
    Related
    ENSP00000322142.7, ENST00000313552.11
    Conserved Domains (2) summary
    cd15685
    Location:187 → 235
    PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
    cd16863
    Location:12 → 104
    ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    241687020..241729478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446012.1 → XP_047301968.1  inhibitor of growth protein 5 isoform X5

  2. XM_047446014.1 → XP_047301970.1  inhibitor of growth protein 5 isoform X7

  3. XM_047446013.1 → XP_047301969.1  inhibitor of growth protein 5 isoform X6

  4. XM_017005102.3 → XP_016860591.1  inhibitor of growth protein 5 isoform X8

    UniProtKB/TrEMBL
    B7Z6R2
    Conserved Domains (1) summary
    pfam12998
    Location:6 → 105
    ING; Inhibitor of growth proteins N-terminal histone-binding

  5. XM_047446011.1 → XP_047301967.1  inhibitor of growth protein 5 isoform X4

    UniProtKB/TrEMBL
    B7Z6R2
    Related
    ENST00000482774.5

  6. XM_017005098.2 → XP_016860587.1  inhibitor of growth protein 5 isoform X3

  7. XM_017005097.2 → XP_016860586.1  inhibitor of growth protein 5 isoform X2

  8. XM_047446010.1 → XP_047301966.1  inhibitor of growth protein 5 isoform X1

RNA

  1. XR_007082548.1 RNA Sequence

  2. XR_007082549.1 RNA Sequence

  3. XR_007082550.1 RNA Sequence

  4. XR_007082546.1 RNA Sequence

  5. XR_007082547.1 RNA Sequence

  6. XR_007082544.1 RNA Sequence

  7. XR_007082545.1 RNA Sequence

  8. XR_007082543.1 RNA Sequence

  9. XR_002959351.2 RNA Sequence

  10. XR_007082542.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    242190352..242233501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344182.1 → XP_054200157.1  inhibitor of growth protein 5 isoform X5

  2. XM_054344184.1 → XP_054200159.1  inhibitor of growth protein 5 isoform X7

  3. XM_054344183.1 → XP_054200158.1  inhibitor of growth protein 5 isoform X6

  4. XM_054344185.1 → XP_054200160.1  inhibitor of growth protein 5 isoform X8

    UniProtKB/TrEMBL
    B7Z6R2

  5. XM_054344181.1 → XP_054200156.1  inhibitor of growth protein 5 isoform X4

    UniProtKB/TrEMBL
    B7Z6R2

  6. XM_054344180.1 → XP_054200155.1  inhibitor of growth protein 5 isoform X3

  7. XM_054344179.1 → XP_054200154.1  inhibitor of growth protein 5 isoform X2

  8. XM_054344178.1 → XP_054200153.1  inhibitor of growth protein 5 isoform X1

RNA

  1. XR_008486553.1 RNA Sequence

  2. XR_008486554.1 RNA Sequence

  3. XR_008486555.1 RNA Sequence

  4. XR_008486551.1 RNA Sequence

  5. XR_008486552.1 RNA Sequence

  6. XR_008486549.1 RNA Sequence

  7. XR_008486550.1 RNA Sequence

  8. XR_008486548.1 RNA Sequence

  9. XR_008486547.1 RNA Sequence

  10. XR_008486546.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WYH8.1 GenPept UniProtKB/Swiss-Prot:Q8WYH8

Gene LinkOut

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