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CUL2 cullin 2 [ Homo sapiens (human) ]

Gene ID: 8453, updated on 3-Nov-2024

Summary

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Official Symbol
CUL2provided by HGNC
Official Full Name
cullin 2provided by HGNC
Primary source
HGNC:HGNC:2552
See related
Ensembl:ENSG00000108094 MIM:603135; AllianceGenome:HGNC:2552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

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See CUL2 in Genome Data Viewer
Location:
10p11.21
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35008551..35127006, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35037104..35155467, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35297479..35379542, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak929 silencer Neighboring gene long intergenic non-protein coding RNA 2635 Neighboring gene uncharacterized LOC124902409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:35301624-35302194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35379443-35379631 Neighboring gene microRNA 3611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3260 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3263 Neighboring gene cAMP responsive element modulator Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma. Jia L, et al. Aging (Albany NY), 2024 May 22. PMID 38787355, Free PMC Article
  2. Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling. Zheng S, et al. Radiother Oncol, 2021 Jan. PMID 32918970
  3. The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer. Liu X, et al. Adv Exp Med Biol, 2020. PMID 31898228
  4. Mutational analysis of hypoxia-related genes HIF1alpha and CUL2 in common human cancers. Park SW, et al. APMIS, 2009 Dec. PMID 20078552
  5. Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma. Hirth CG, et al. Ann Diagn Pathol, 2022 Feb. PMID 34717191

See all (272) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAF2 associates with cullin neddylation complex assembly.
    Title: TRAF2 associates with cullin neddylation complex assembly.
  2. Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma.
    Title: Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma.
  3. MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
    Title: MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo.
  4. MicroRNA-574-3p Regulates HIF-alpha Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
    Title: MicroRNA-574-3p Regulates HIF-α Isoforms Promoting Gastric Cancer Epithelial-Mesenchymal Transition via Targeting CUL2.
  5. A close shave: How SARS-CoV-2 induces the loss of cilia.
    Title: A close shave: How SARS-CoV-2 induces the loss of cilia.
  6. CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
    Title: CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.
  7. Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
    Title: Immunoexpression of HSPA9 and CUL2 in prostatic tissue and adenocarcinoma.
  8. Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
    Title: Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
  9. Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
    Title: Integrating cullin2-RING E3 ligase as a potential biomarker for glioblastoma multiforme prognosis and radiosensitivity profiling.
  10. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
    Title: ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with Cullin 2 (CUL2) in human HEK293 and/or Jurkat cell lines PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131970

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase complex scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of VCB complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cullin-2
Names
CUL-2
testis secretory sperm-binding protein Li 238E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198777.2 → NP_001185706.1  cullin-2 isoform c

    See identical proteins and their annotated locations for NP_001185706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AI089201, AK095217, AL392046, BC009591
    Consensus CDS
    CCDS7179.1
    UniProtKB/Swiss-Prot
    B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
    UniProtKB/TrEMBL
    A0A140VKB1, A0A8I5KUA9
    Related
    ENSP00000363883.3, ENST00000374751.7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  2. NM_001198778.2 → NP_001185707.1  cullin-2 isoform a

    See identical proteins and their annotated locations for NP_001185707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI089201, AL392046, BC009591, DC401811
    Consensus CDS
    CCDS55709.1
    UniProtKB/TrEMBL
    A0A8I5QJI3
    Related
    ENSP00000414095.2, ENST00000421317.5
    Conserved Domains (2) summary
    pfam00888
    Location:34 → 662
    Cullin; Cullin family
    pfam10557
    Location:696 → 754
    Cullin_Nedd8; Cullin protein neddylation domain

  3. NM_001198779.1 → NP_001185708.1  cullin-2 isoform b

    See identical proteins and their annotated locations for NP_001185708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI089201, AK310225, AL392046, BC009591, DC401811
    Consensus CDS
    CCDS73086.1
    UniProtKB/TrEMBL
    A0A0A0MTN0, A0A8I5QJI3
    Related
    ENSP00000444856.2, ENST00000537177.6
    Conserved Domains (2) summary
    pfam00888
    Location:28 → 656
    Cullin; Cullin family
    pfam10557
    Location:690 → 748
    Cullin_Nedd8; Cullin protein neddylation domain

  4. NM_001324375.2 → NP_001311304.1  cullin-2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AK294080, AL392046
    Consensus CDS
    CCDS91236.1
    UniProtKB/TrEMBL
    A0A8I5KUA9, A0A8I5KVR3
    Related
    ENSP00000508924.1, ENST00000690123.1

  5. NM_001324376.2 → NP_001311305.1  cullin-2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AK310225, AL392046
    UniProtKB/TrEMBL
    A0A8I5KUA9
    Conserved Domains (2) summary
    pfam00888
    Location:5 → 512
    Cullin; Cullin family
    pfam10557
    Location:546 → 604
    Cullin_Nedd8; Cullin protein neddylation domain

  6. NM_003591.4 → NP_003582.2  cullin-2 isoform c

    See identical proteins and their annotated locations for NP_003582.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AI089201, AL392046, BC009591, DC401936
    Consensus CDS
    CCDS7179.1
    UniProtKB/Swiss-Prot
    B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
    UniProtKB/TrEMBL
    A0A140VKB1, A0A8I5KUA9
    Related
    ENSP00000363881.3, ENST00000374749.8
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    35008551..35127006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519745.2 → XP_011518047.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_011518047.1

    UniProtKB/TrEMBL
    A0A8I5QJI3
    Conserved Domains (3) summary
    smart00182
    Location:487 → 631
    CULLIN; Cullin
    smart00884
    Location:735 → 802
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:93 → 706
    Cullin; Cullin family

  2. XM_047425852.1 → XP_047281808.1  cullin-2 isoform X1

  3. XM_011519743.1 → XP_011518045.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_011518045.1

    UniProtKB/TrEMBL
    A0A8I5QJI3
    Conserved Domains (3) summary
    smart00182
    Location:487 → 631
    CULLIN; Cullin
    smart00884
    Location:735 → 802
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:93 → 706
    Cullin; Cullin family

  4. XM_011519744.1 → XP_011518046.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_011518046.1

    UniProtKB/TrEMBL
    A0A8I5QJI3
    Conserved Domains (3) summary
    smart00182
    Location:487 → 631
    CULLIN; Cullin
    smart00884
    Location:735 → 802
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:93 → 706
    Cullin; Cullin family

  5. XM_011519747.2 → XP_011518049.1  cullin-2 isoform X2

    See identical proteins and their annotated locations for XP_011518049.1

    UniProtKB/Swiss-Prot
    B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
    UniProtKB/TrEMBL
    A0A140VKB1, A0A8I5KUA9
    Related
    ENSP00000363880.1, ENST00000374748.5
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    35037104..35155467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366953.1 → XP_054222928.1  cullin-2 isoform X1

  2. XM_054366954.1 → XP_054222929.1  cullin-2 isoform X1

  3. XM_054366951.1 → XP_054222926.1  cullin-2 isoform X1

  4. XM_054366952.1 → XP_054222927.1  cullin-2 isoform X1

  5. XM_054366955.1 → XP_054222930.1  cullin-2 isoform X2

    UniProtKB/Swiss-Prot
    B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q13617, Q5T2B6, Q9UNF9
    UniProtKB/TrEMBL
    A0A140VKB1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13617.2 GenPept UniProtKB/Swiss-Prot:Q13617

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