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MCHR2 melanin concentrating hormone receptor 2 [ Homo sapiens (human) ]

Gene ID: 84539, updated on 10-Dec-2024

Summary

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Official Symbol
MCHR2provided by HGNC
Official Full Name
melanin concentrating hormone receptor 2provided by HGNC
Primary source
HGNC:HGNC:20867
See related
Ensembl:ENSG00000152034 MIM:606111; AllianceGenome:HGNC:20867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLT; MCH2; MCH2R; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2
Summary
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in brain (RPKM 3.0) and testis (RPKM 2.4) See more
Orthologs
all
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Genomic context

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See MCHR2 in Genome Data Viewer
Location:
6q16.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (99918519..99994223, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (101091896..101168099, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (100366395..100442099, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:100023517-100023714 Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24863 Neighboring gene CCNC and PRDM13 intergenic region DNase I hypersensitve site DHS6S1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100051429-100052268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100061850-100062398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17423 Neighboring gene ribosomal protein S3 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:100097329-100097949 Neighboring gene PR/SET domain 13 Neighboring gene Sharpr-MPRA regulatory region 7231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:100271711-100272281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:100379521-100380020 Neighboring gene MCHR2 antisense RNA 1 Neighboring gene tetratricopeptide repeat domain 22 pseudogene Neighboring gene nucleophosmin 1 pseudogene 38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. DNA sequencing and copy number variation analysis of MCHR2 in a cohort of Prader Willi like (PWL) patients. Geets E, et al. Obes Res Clin Pract, 2018 Mar-Apr. PMID 29066024
  2. Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2. Fischer J, et al. Exp Dermatol, 2017 Jun. PMID 27306922
  3. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Mori M, et al. Biochem Biophys Res Commun, 2001 May 25. PMID 11355873
  4. Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Chen X, et al. Bioorg Med Chem Lett, 2012 Jan 1. PMID 22123324
  5. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. Wang S, et al. J Biol Chem, 2001 Sep 14. PMID 11459838

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results are in line with some previously performed studies suggesting that MCHR2 is not a major contributor to human obesity and the Prader Willi Syndrome phenotype
    Title: DNA sequencing and copy number variation analysis of MCHR2 in a cohort of Prader Willi like (PWL) patients.
  2. evidence for the involvement of duplications in MCHR2 in alopecia areata pathogenesis in a Central European cohort
    Title: Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2.
  3. This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.
    Title: Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.
  4. Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2
    Title: Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
  5. construction of the CHO cell line and the research of MCHR2 molecular characteristics have established a good experimental basis for the further research about the function of MCHR2 gene
    Title: Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics.
  6. MCHR2 positively mediates the regulation of melanin-concentrating hormone during preadipocyte differentiation and is involved in energy balance regulation without affecting preadipocyte proliferation.
    Title: Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.
  7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.
  9. MCHR2 is not a major contributor to polygenic obesity
    Title: Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
  10. results of molecular simulations of MCHR2 in the free and hormone-bound forms provide suggestions on the amino acids responsible for the transfer of the structural changes from the agonist binding site to the G-protein coupling domains
    Title: Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
melanin-concentrating hormone receptor 2
Names
G protein-coupled receptor slt
G-protein coupled receptor 145
MCH receptor 2
melanin-concentrating hormone 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040179.2 → NP_001035269.1  melanin-concentrating hormone receptor 2

    See identical proteins and their annotated locations for NP_001035269.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK123634, AL590725
    Consensus CDS
    CCDS5044.1
    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
    Related
    ENSP00000281806.2, ENST00000281806.7
    Conserved Domains (1) summary
    cd15339
    Location:35 → 317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_032503.3 → NP_115892.2  melanin-concentrating hormone receptor 2

    See identical proteins and their annotated locations for NP_115892.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK123634, AL590725
    Consensus CDS
    CCDS5044.1
    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
    Related
    ENSP00000358214.1, ENST00000369212.2
    Conserved Domains (1) summary
    cd15339
    Location:35 → 317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    99918519..99994223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446571.2 → XP_024302339.1  melanin-concentrating hormone receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
    Conserved Domains (1) summary
    cd15339
    Location:35 → 317
    7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    101091896..101168099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356560.1 → XP_054212535.1  melanin-concentrating hormone receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969V1.1 GenPept UniProtKB/Swiss-Prot:Q969V1

Gene LinkOut

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