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IL1F10 interleukin 1 family member 10 [ Homo sapiens (human) ]

Gene ID: 84639, updated on 26-Nov-2024

Summary

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Official Symbol
IL1F10provided by HGNC
Official Full Name
interleukin 1 family member 10provided by HGNC
Primary source
HGNC:HGNC:15552
See related
Ensembl:ENSG00000136697 MIM:615296; AllianceGenome:HGNC:15552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 1.0) See more
Orthologs
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Genomic context

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See IL1F10 in Genome Data Viewer
Location:
2q14.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113067970..113075843)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113494498..113502373)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113825547..113833420)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 36 beta Neighboring gene Sharpr-MPRA regulatory region 4990 Neighboring gene interleukin 36 receptor antagonist Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:113835447-113836646 Neighboring gene Sharpr-MPRA regulatory region 10370 Neighboring gene RNA, U6 small nuclear 1180, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16411 Neighboring gene interleukin 1 receptor antagonist Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16412

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder. Tsilioni I, et al. Proc Natl Acad Sci U S A, 2020 Jul 14. PMID 32601180, Free PMC Article
  2. Interleukin-38 Suppresses Cell Migration and Proliferation and Promotes Apoptosis of Colorectal Cancer Cell Through Negatively Regulating Extracellular Signal-Regulated Kinases Signaling. Huang L, et al. J Interferon Cytokine Res, 2021 Oct. PMID 34612721
  3. Aberrant Expression of Novel Cytokine IL-38 and Regulatory T Lymphocytes in Childhood Asthma. Chu M, et al. Molecules, 2016 Jul 18. PMID 27438823, Free PMC Article
  4. The elevated expression of IL-38 serves as an anti-inflammatory factor in osteoarthritis and its protective effect in osteoarthritic chondrocytes. Jiang L, et al. Int Immunopharmacol, 2021 May. PMID 33774357
  5. Biology of interleukin-38 and its role in chronic inflammatory diseases. Xia HS, et al. Int Immunopharmacol, 2021 Jun. PMID 33725637

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-38: A crucial player in periodontitis.
    Title: Interleukin-38: A crucial player in periodontitis.
  2. Neutralizing IL-38 activates gammadelta T cell-dependent antitumor immunity and sensitizes for chemotherapy.
    Title: Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy.
  3. IL-38 promotes the development of prostate cancer.
    Title: IL-38 promotes the development of prostate cancer.
  4. The 5' untranslated region variant rs3811050 C/T of the interleukin-38 encoding gene is associated with susceptibility to rheumatoid arthritis in Iraqi women.
    Title: The 5' untranslated region variant rs3811050 C/T of the interleukin-38 encoding gene is associated with susceptibility to rheumatoid arthritis in Iraqi women.
  5. Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors.
    Title: Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors.
  6. Interleukin-38 and Insulin Resistance.
    Title: Interleukin-38 and Insulin Resistance.
  7. Emerging functions and therapeutic targets of IL-38 in central nervous system diseases.
    Title: Emerging functions and therapeutic targets of IL-38 in central nervous system diseases.
  8. IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis.
    Title: IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis.
  9. IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1beta secretion.
    Title: IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion.
  10. Assessment of the levels of interleukin-17 and interleukin-38 in thyroid-associated ophthalmopathy patients.
    Title: Assessment of the levels of interleukin-17 and interleukin-38 in thyroid-associated ophthalmopathy patients.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
EBI GWAS Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
EBI GWAS Catalog
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-1 family member 10
Names
FIL1 theta
IL-1 theta
IL-1F10 (canonical form IL-1F10a)
family of interleukin 1-theta
interleukin 1 family member 10 (theta)
interleukin-1 HY2
interleukin-1 receptor antagonist FKSG75
interleukin-1 receptor antagonist-like FIL1 theta
interleukin-38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032556.6 → NP_115945.4  interleukin-1 family member 10

    See identical proteins and their annotated locations for NP_115945.4

    Status: REVIEWED

    Source sequence(s)
    AC016724, AF334755, AY358846
    Consensus CDS
    CCDS2112.1
    UniProtKB/Swiss-Prot
    Q53SR9, Q56AT8, Q7RTZ5, Q8WWZ1, Q969H5, Q9BYX1
    Related
    ENSP00000376893.2, ENST00000393197.3
    Conserved Domains (1) summary
    cl00094
    Location:10 → 149
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

  2. NM_173161.3 → NP_775184.1  interleukin-1 family member 10

    See identical proteins and their annotated locations for NP_775184.1

    Status: REVIEWED

    Source sequence(s)
    AY029413, AY358846
    Consensus CDS
    CCDS2112.1
    UniProtKB/Swiss-Prot
    Q53SR9, Q56AT8, Q7RTZ5, Q8WWZ1, Q969H5, Q9BYX1
    Related
    ENSP00000341794.2, ENST00000341010.6
    Conserved Domains (1) summary
    cl00094
    Location:10 → 149
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    113067970..113075843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    113494498..113502373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWZ1.1 GenPept UniProtKB/Swiss-Prot:Q8WWZ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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