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TNS4 tensin 4 [ Homo sapiens (human) ]

Gene ID: 84951, updated on 10-Dec-2024

Summary

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Official Symbol
TNS4provided by HGNC
Official Full Name
tensin 4provided by HGNC
Primary source
HGNC:HGNC:24352
See related
Ensembl:ENSG00000131746 MIM:608385; AllianceGenome:HGNC:24352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTEN; PP14434
Summary
Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues See more
Orthologs
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Genomic context

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See TNS4 in Genome Data Viewer
Location:
17q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40475834..40501623, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41339341..41365145, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38632086..38657875, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8491 Neighboring gene ribosomal protein L23a pseudogene 75 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8493 Neighboring gene insulin like growth factor binding protein 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627029-38627920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627921-38628810 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:38636369-38637568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38637551-38637736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38646739-38647364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38649729-38650230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38650231-38650730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38655417-38656288 Neighboring gene uncharacterized LOC105371773 Neighboring gene Sharpr-MPRA regulatory region 2600 Neighboring gene uncharacterized LOC107985090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression. Heo H, et al. Mol Cells, 2023 May 31. PMID 36896596, Free PMC Article
  2. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Lo SH, et al. Cancer Res, 2002 Aug 1. PMID 12154022
  3. Cten mRNA expression was correlated with tumor progression in lung cancers. Sasaki H, et al. Lung Cancer, 2003 May. PMID 12711115
  4. Tensins: a new switch in cell migration. Mouneimne G, et al. Dev Cell, 2007 Sep. PMID 17765673
  5. Prognostic relevance of Tensin4 expression in human gastric cancer. Sakashita K, et al. Ann Surg Oncol, 2008 Sep. PMID 18612693

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
    Title: GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
  2. Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
    Title: Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
  3. Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
    Title: Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
  4. Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
    Title: Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
  5. CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of beta-Catenin in Breast Cancer.
    Title: CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of β-Catenin in Breast Cancer.
  6. Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
    Title: Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
  7. Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
    Title: Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
  8. Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3beta/snail signaling pathway.
    Title: Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3β/snail signaling pathway.
  9. The authors propose that TNS4 plays a crucial role in CRC tumorigenesis, and that suppression of TNS4 would be an effective therapeutic strategy in treating a subset of cetuximab-refractory CRC patients including KRAS activating mutations.
    Title: Whole Transcriptome Analysis Identifies TNS4 as a Key Effector of Cetuximab and a Regulator of the Oncogenic Activity of KRAS Mutant Colorectal Cancer Cell Lines.
  10. analysis of cten force-induced recruitment along keratin network in epithelial cells
    Title: Force-induced recruitment of cten along keratin network in epithelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14950

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tensin-4
Names
C terminal tensin like
C-terminal tensin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032865.6 → NP_116254.4  tensin-4 precursor

    See identical proteins and their annotated locations for NP_116254.4

    Status: VALIDATED

    Source sequence(s)
    AC018629, AF417488, AW378527, AW937802, BC018706, BM710196
    Consensus CDS
    CCDS11368.1
    UniProtKB/Swiss-Prot
    A6NMJ7, Q71RB7, Q8IZW8, Q8WV64, Q96JV4
    UniProtKB/TrEMBL
    A0A2Z4HJF2
    Related
    ENSP00000254051.6, ENST00000254051.11
    Conserved Domains (2) summary
    cd01213
    Location:580 → 710
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cl15255
    Location:445 → 558
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    40475834..40501623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257744.2 → XP_005257801.1  tensin-4 isoform X2

    UniProtKB/TrEMBL
    A0A2Z4HJF2
    Conserved Domains (2) summary
    cd01213
    Location:579 → 709
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cl15255
    Location:444 → 557
    SH2; Src homology 2 (SH2) domain

  2. XM_017025236.2 → XP_016880725.1  tensin-4 isoform X3

    UniProtKB/TrEMBL
    A0A2Z4HJF2

  3. XM_047436949.1 → XP_047292905.1  tensin-4 isoform X1

    UniProtKB/TrEMBL
    A0A2Z4HJF2

  4. XM_047436950.1 → XP_047292906.1  tensin-4 isoform X5

  5. XM_017025237.2 → XP_016880726.1  tensin-4 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41339341..41365145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317591.1 → XP_054173566.1  tensin-4 isoform X2

    UniProtKB/TrEMBL
    A0A2Z4HJF2

  2. XM_054317592.1 → XP_054173567.1  tensin-4 isoform X3

    UniProtKB/TrEMBL
    A0A2Z4HJF2

  3. XM_054317590.1 → XP_054173565.1  tensin-4 isoform X1

    UniProtKB/TrEMBL
    A0A2Z4HJF2

  4. XM_054317595.1 → XP_054173570.1  tensin-4 isoform X6

  5. XM_054317594.1 → XP_054173569.1  tensin-4 isoform X5

  6. XM_054317593.1 → XP_054173568.1  tensin-4 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZW8.3 GenPept UniProtKB/Swiss-Prot:Q8IZW8

Gene LinkOut

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