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MIR22HG MIR22 host gene [ Homo sapiens (human) ]

Gene ID: 84981, updated on 4-Jan-2025

Summary

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Official Symbol
MIR22HGprovided by HGNC
Official Full Name
MIR22 host geneprovided by HGNC
Primary source
HGNC:HGNC:28219
See related
Ensembl:ENSG00000186594 AllianceGenome:HGNC:28219
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf91
Summary
Predicted to act upstream of or within response to wounding. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in adrenal (RPKM 35.5), bone marrow (RPKM 31.9) and 24 other tissues See more
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Genomic context

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See MIR22HG in Genome Data Viewer
Location:
17p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1711504..1716210, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1600429..1605139, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1614798..1619504, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1554397-1554907 Neighboring gene pre-mRNA processing factor 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1593390-1593890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1593891-1594391 Neighboring gene TLC domain containing 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1619651-1620292 Neighboring gene microRNA 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1627561-1628061 Neighboring gene WD repeat domain 81 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1638655-1639172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1639173-1639688 Neighboring gene Sharpr-MPRA regulatory region 4635 Neighboring gene serpin family F member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1655564-1656124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis. Chen X, et al. Clin Nutr, 2024 Jan. PMID 38011754
  2. Identification of Long Noncoding RNA MIR22HG as a Novel Biomarker in Thyroid Cancer. Qin L, et al. Pathol Oncol Res, 2019 Apr. PMID 30539522
  3. Long non-coding RNA MIR22HG inhibits cell proliferation and migration in cholangiocarcinoma by negatively regulating the Wnt/β-catenin signaling pathway. Hu X, et al. J Gene Med, 2019 May. PMID 30856284
  4. LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling. Su W, et al. Aging (Albany NY), 2019 Jul 10. PMID 31291201, Free PMC Article
  5. Long noncoding RNA MIR22HG is down-regulated in prostate cancer. Shen H, et al. Math Biosci Eng, 2019 Dec 17. PMID 32233607

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis.
    Title: LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis.
  2. Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
    Title: Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
  3. Long non-coding RNA MIR22HG inhibits the proliferation and migration, and promotes apoptosis by targeting microRNA-9-3p/ SOCS1 axis in small cell lung cancer cells.
    Title: Long non-coding RNA MIR22HG inhibits the proliferation and migration, and promotes apoptosis by targeting microRNA-9-3p/ SOCS1 axis in small cell lung cancer cells.
  4. Long non-coding RNA MIR22HG suppresses cell proliferation and promotes apoptosis in prostate cancer cells by sponging microRNA-9-3p.
    Title: Long non-coding RNA MIR22HG suppresses cell proliferation and promotes apoptosis in prostate cancer cells by sponging microRNA-9-3p.
  5. [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].
    Title: [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].
  6. Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis.
    Title: Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis.
  7. MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
    Title: MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
  8. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
    Title: LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
  9. Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells.
    Title: Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells.
  10. Long noncoding RNA MIR22HG is down-regulated in prostate cancer.
    Title: Long noncoding RNA MIR22HG is down-regulated in prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
EBI GWAS Catalog
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • MIR22 host gene (non-protein coding)

Clone Names

  • MGC14376, MGC149751, DKFZp686O06159

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028502.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000574306.3

  2. NR_028503.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000575626.7

  3. NR_028504.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000334146.10

  4. NR_028505.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000690262.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    1711504..1716210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187611.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    141532..146238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    1600429..1605139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001870.1: Suppressed sequence

    Description
    NM_001001870.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

  2. NM_032895.2: Suppressed sequence

    Description
    NM_032895.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VDD5.1 GenPept UniProtKB/Swiss-Prot:Q0VDD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials