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HMLALPHA1 transcriptional co-activator mating type protein alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 850293, updated on 2-Nov-2024

Summary

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Official Symbol
HMLALPHA1
Official Full Name
transcriptional co-activator mating type protein alpha
Primary source
SGD:S000000571
Locus tag
YCL066W
See related
AllianceGenome:SGD:S000000571; FungiDB:YCL066W; VEuPathDB:YCL066W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ALPHA1
Summary
Predicted to enable DNA binding activity, bending and transcription coactivator activity. Predicted to be involved in regulation of mating-type specific transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HMLALPHA1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (13282..13809)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homeodomain mating type protein alpha2 Neighboring gene L-serine/L-threonine ammonia-lyase CHA1 Neighboring gene Vac17p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins. Yuan YO, et al. Genes Dev, 1993 Aug. PMID 8339934
  2. The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site. Grayhack EJ. Mol Cell Biol, 1992 Aug. PMID 1630462, Free PMC Article
  3. Lack of a requirement for strict rotational alignment among transcription factor binding sites in yeast. Inokuchi K, et al. Nucleic Acids Res, 1991 Jun 11. PMID 1905400, Free PMC Article
  4. Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris. Bader O, et al. BMC Microbiol, 2008 Jul 14. PMID 18625069, Free PMC Article
  5. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Tan S, et al. Cell, 1990 Jul 27. PMID 2164891

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding, bending IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding, bending ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables transcription coactivator activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of mating-type specific transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mating-type specific transcription, DNA-templated ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
transcriptional co-activator mating type protein alpha
NP_009867.1
  • Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    13282..13809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178707.1 → NP_009867.1  TPA: transcriptional co-activator mating type protein alpha [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009867.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQV3, P01365, P0CY06, P0CY07
    UniProtKB/TrEMBL
    A6ZTM2, B3LU21, C8Z425, G2WA58
    Conserved Domains (1) summary
    pfam04769
    Location:84 → 143
    MATalpha_HMGbox; Mating-type protein MAT alpha 1 HMG-box
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CY06.1
P0CY07.1

Gene LinkOut

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Molecular Biology Databases
Research Materials