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BUD5 Ras family guanine nucleotide exchange factor BUD5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850405, updated on 2-Nov-2024

Summary

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Official Symbol
BUD5
Official Full Name
Ras family guanine nucleotide exchange factor BUD5
Primary source
SGD:S000000634
Locus tag
YCR038C
See related
AllianceGenome:SGD:S000000634; FungiDB:YCR038C; VEuPathDB:YCR038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in axial cellular bud site selection and bipolar cellular bud site selection. Located in cellular bud neck and incipient cellular bud site. Human ortholog(s) of this gene implicated in hypertension; immunodeficiency 64; and platelet-type bleeding disorder 18. Orthologous to several human genes including RASGRP1 (RAS guanyl releasing protein 1); RASGRP2 (RAS guanyl releasing protein 2); and RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BUD5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (197621..199549, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative ribokinase Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene homeodomain mating type protein alpha2 Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene uncharacterized protein Neighboring gene Taf2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1. Chant J, et al. Cell, 1991 Jun 28. PMID 1905981
  2. Development of pseudohyphae by embedded haploid and diploid yeast. Lo WS, et al. Curr Genet, 1997 Sep. PMID 9339344
  3. Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast. Kang PJ, et al. J Biol Chem, 2004 Jul 2. PMID 15136576
  4. Cell polarity: connecting to the cortex. Arkowitz RA. Curr Biol, 2001 Aug 7. PMID 11516968
  5. A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity. Kang PJ, et al. Science, 2001 May 18. PMID 11313501, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axial cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bipolar cellular bud site selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ras family guanine nucleotide exchange factor BUD5
NP_009967.2
  • GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    197621..199549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178752.1 → NP_009967.2  TPA: Ras family guanine nucleotide exchange factor BUD5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009967.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR48, P25300, Q06729
    UniProtKB/TrEMBL
    A6ZTM0, C8Z4C8, G2WA56
    Conserved Domains (2) summary
    smart00147
    Location:409 → 640
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:230 → 339
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25300.2

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