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MATALPHA1 transcriptional co-activator mating type protein alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 850407, updated on 18-Sep-2024

Summary

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Official Symbol
MATALPHA1
Official Full Name
transcriptional co-activator mating type protein alpha
Primary source
SGD:S000000636
Locus tag
YCR040W
See related
AllianceGenome:SGD:S000000636; FungiDB:YCR040W; VEuPathDB:YCR040W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ALPHA1
Summary
Enables DNA binding activity, bending and transcription coactivator activity. Involved in regulation of mating-type specific transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MATALPHA1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (200442..200969)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene Ras family guanine nucleotide exchange factor BUD5 Neighboring gene homeodomain mating type protein alpha2 Neighboring gene uncharacterized protein Neighboring gene Taf2p Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation affecting sexual agglutinability in MATα locus of Saccharomyces cerevisiae. Doi S, et al. Curr Genet, 1985 Mar. PMID 24173553
  2. Tracing the origin of the fungal α1 domain places its ancestor in the HMG-box superfamily: implication for fungal mating-type evolution. Martin T, et al. PLoS One, 2010 Dec 8. PMID 21170349, Free PMC Article
  3. Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins. Yuan YO, et al. Genes Dev, 1993 Aug. PMID 8339934
  4. Physical analysis of mating-type loci in Saccharomyces cerevisiae. Nasmyth KA, et al. Cold Spring Harb Symp Quant Biol, 1981. PMID 7021055
  5. Control of yeast cell type by the mating type locus: positive regulation of the alpha-specific STE3 gene by the MAT alpha 1 product. Sprague GF Jr, et al. Cell, 1983 Feb. PMID 6337727

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding, bending IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of mating-type specific transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mating-type specific transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcriptional co-activator mating type protein alpha
NP_009869.3
  • Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    200442..200969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178754.1 → NP_009869.3  TPA: transcriptional co-activator mating type protein alpha [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009869.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQV3, P01365, P0CY06, P0CY07
    UniProtKB/TrEMBL
    A6ZTM2, B3LU21, C8Z425, G2WA58
    Conserved Domains (1) summary
    pfam04769
    Location:84 → 143
    MATalpha_HMGbox; Mating-type protein MAT alpha 1 HMG-box
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CY06.1
P0CY07.1

Gene LinkOut

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Molecular Biology Databases
Research Materials