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AGP3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850489, updated on 11-Sep-2024

Summary

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Official Symbol
AGP3
Primary source
SGD:S000001839
Locus tag
YFL055W
See related
AllianceGenome:SGD:S000001839; FungiDB:YFL055W; VEuPathDB:YFL055W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables amino acid transmembrane transporter activity. Involved in amino acid transport and transmembrane transport. Located in endoplasmic reticulum. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (17004..18680)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene pseudo Neighboring gene Aqy3p Neighboring gene dihydroxyacetone kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Agp2p and Agp3p function as amino acid permeases in poor nutrient conditions. Schreve JL, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697254
  2. The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. Boer VM, et al. J Biol Chem, 2003 Jan 31. PMID 12414795
  3. Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis. Nyswaner KM, et al. Genetics, 2008 Jan. PMID 18202368, Free PMC Article
  4. Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Regenberg B, et al. Curr Genet, 1999 Dec. PMID 10654085
  5. The antifungal eugenol perturbs dual aromatic and branched-chain amino acid permeases in the cytoplasmic membrane of yeast. Darvishi E, et al. PLoS One, 2013. PMID 24204588, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Agp3p
NP_116600.1
  • Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    17004..18680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179912.1 → NP_116600.1  TPA: Agp3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTH5, P43548
    UniProtKB/TrEMBL
    A6ZQC1, G2WD86, N1P4Z9
    Conserved Domains (1) summary
    TIGR00913
    Location:50 → 517
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43548.1

Gene LinkOut

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