BLM10 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BLM10
Primary source: SGD:S000001887
Locus tag: YFL007W
See related: AllianceGenome:SGD:S000001887; FungiDB:YFL007W; VEuPathDB:YFL007W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YFL006W
Summary: Enables peptidase activator activity and proteasome binding activity. Involved in several processes, including proteasome assembly; proteasome core complex import into nucleus; and proteasome storage granule assembly. Located in nucleus and proteasome storage granule. Orthologous to human PSME4 (proteasome activator subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (123479..129910)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteasome activator Blm10 levels and autophagic degradation directly impact the proteasome landscape.
Title: Proteasome activator Blm10 levels and autophagic degradation directly impact the proteasome landscape.
The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.
Title: The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.
Transcriptional upregulation of proteasome activator Blm10 antagonizes cellular aging.
Title: Transcriptional upregulation of proteasome activator Blm10 antagonizes cellular aging.
data are consistent with a model in which Blm10 proteasome-mediated turnover of Dnm1 is required for the maintenance of mitochondrial function
Title: Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1.
Blm10 represents the first proteolytic core particle-dedicated nuclear import receptor in yeast.
Title: Blm10 facilitates nuclear import of proteasome core particles.
Data propose that the cellular function of Blm10 is based on central core of the proteasome association and activation to promote the degradation of proteasome substrates.
Title: Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism.
Blm10 functions in a proteasome-related process and it is required for the maintenance of mitochondrial function.
Title: Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.
Blm10 distinguishes between gate conformations and regulates the activation of core particles.
Title: Blm10 binds to pre-activated proteasome core particles with open gate conformation.
Blm10 and the 19 S activator with Pre4 have a partially redundant function in stabilizing nascent 20 S proteasomes and in promoting their activation
Title: The C-terminal extension of the beta7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturation.
Synthetic interactions between blm10Delta and other mutations that impair proteasome function show that Blm10 functions together with proteasomes in vivo
Title: The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

rep_origin

Loc: 127751-128071

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IDA Inferred from Direct Assay more info	PubMed
enables proteasome binding	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in proteasomal ubiquitin-independent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome core complex import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome storage granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in proteasome storage granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Blm10p

NP_116648.2

Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

123479..129910

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179959.1 → NP_116648.2 TPA: Blm10p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116648.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTM3, P43583, P43584

UniProtKB/TrEMBL

A7A232, G2WDD4

Conserved Domains (3) summary

pfam11919
Location:2056 → 2142

DUF3437; Domain of unknown function (DUF3437)

pfam16507
Location:511 → 1030

BLM10_mid; Proteasome-substrate-size regulator, mid region

pfam16547
Location:79 → 159

BLM10_N; Proteasome-substrate-size regulator, N-terminal