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LSB3 Lsb3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850580, updated on 2-Nov-2024

Summary

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Official Symbol
LSB3
Official Full Name
Lsb3p
Primary source
SGD:S000002968
Locus tag
YFR024C-A
See related
AllianceGenome:SGD:S000002968; FungiDB:YFR024C-A; VEuPathDB:YFR024C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YFR024C
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol binding activity. Involved in actin cortical patch localization. Located in cellular bud neck and mitochondrion. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LSB3 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
2
Sequence:
Chromosome: VI; NC_001138.5 (201960..203433, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Pes4p Neighboring gene histidinol-phosphatase Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Optimization of specificity in a cellular protein interaction network by negative selection. Zarrinpar A, et al. Nature, 2003 Dec 11. PMID 14668868
  2. Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis. Lamb AK, et al. J Cell Biol, 2024 Jan 1. PMID 37966720, Free PMC Article
  3. The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Madania A, et al. Mol Biol Cell, 1999 Oct. PMID 10512884, Free PMC Article
  4. Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling. Bergeron-Sandoval LP, et al. Proc Natl Acad Sci U S A, 2021 Dec 14. PMID 34887356, Free PMC Article
  5. Characterization of the yeast trimeric-SAS acetyltransferase complex. Shia WJ, et al. J Biol Chem, 2005 Mar 25. PMID 15659401

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our analysis suggests a novel role for the SH3 domains of Lsb3p and Lsb4p as hubs that recruit and assemble several endocytic complexes.
    Title: Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin cortical patch localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellular bud neck HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Lsb3p
NP_219497.4
  • Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    201960..203433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180865.3 → NP_219497.4  TPA: Lsb3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_219497.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A261, D6VTQ4, P43603
    UniProtKB/TrEMBL
    C7GYC9, C8Z7V9, N1P394
    Conserved Domains (2) summary
    cd11842
    Location:404 → 458
    SH3_Ysc84p_like; Src homology 3 domain of Ysc84p and similar fungal proteins
    COG2930
    Location:1 → 219
    SYLF; Lipid-binding SYLF domain [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43603.3

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