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KNS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850641, updated on 11-Sep-2024

Summary

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Official Symbol
KNS1
Primary source
SGD:S000003942
Locus tag
YLL019C
See related
AllianceGenome:SGD:S000003942; FungiDB:YLL019C; VEuPathDB:YLL019C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in negative regulation of transcription by RNA polymerase III; peptidyl-serine phosphorylation; and protein autophosphorylation. Located in cytoplasm and nucleus. Orthologous to several human genes including CLK1 (CDC like kinase 1); CLK2 (CDC like kinase 2); and CLK3 (CDC like kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (105686..107899, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Hif1p Neighboring gene Spa2p Neighboring gene Cox19p Neighboring gene aspartate--tRNA ligase DPS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER kinase homolog. Kim KH, et al. Biochem Biophys Res Commun, 2001 Dec 21. PMID 11741326
  2. The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family. Padmanabha R, et al. Mol Gen Genet, 1991 Sep. PMID 1910150
  3. TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases. Lee J, et al. Mol Cell, 2012 Mar 30. PMID 22364741, Free PMC Article
  4. Activity and autophosphorylation of LAMMER protein kinases. Lee K, et al. J Biol Chem, 1996 Nov 1. PMID 8910305
  5. TORC1 signaling regulates cytoplasmic pH through Sir2 in yeast. Devare MN, et al. Aging Cell, 2020 Jun. PMID 32449834, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ckb1 is differentially phosphorylated in vivo and that Kns1 mediates this phosphorylation when nutrients are limiting and under all tested stress conditions.
    Title: Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.
  2. Kns1 and Mck1 are conserved protein kinases that function downstream of TORC1. Efficient repression of ribosome and tRNA synthesis requires Kns1 and Mck1
    Title: TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase KNS1
NP_013081.1
  • Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    105686..107899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181839.1 → NP_013081.1  TPA: serine/threonine protein kinase KNS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXY4, P32350, Q12399
    UniProtKB/TrEMBL
    A7A0N7, B3LTF0, B5VMS7, C8ZCV3
    Conserved Domains (1) summary
    cd14134
    Location:298 → 720
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32350.2

Gene LinkOut

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