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EMC6 Emc6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850646, updated on 1-Aug-2024

Summary

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Gene symbol
EMC6
Gene description
Emc6p
Primary source
FungiDB:YLL014W
Locus tag
YLL014W
See related
SGD:S000003937; AllianceGenome:SGD:S000003937; VEuPathDB:YLL014W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. Orthologous to human EMC6 (ER membrane protein complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EMC6 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (121322..121648)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ATP-binding cassette bilirubin transporter BPT1 Neighboring gene mRNA-binding protein PUF3 Neighboring gene sterol esterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
  2. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
  3. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
  4. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
  5. Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects. Lakshminarayan R, et al. Curr Biol, 2020 Mar 9. PMID 31956032, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding in endoplasmic reticulum HGI PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of EMC complex IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Emc6p
NP_013087.1
  • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    121322..121648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181834.1 → NP_013087.1  TPA: Emc6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013087.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXY8, Q12431
    UniProtKB/TrEMBL
    A7A0P2, B3LTF4, C8ZCV9, G2WII1, N1NYU6
    Conserved Domains (1) summary
    pfam07019
    Location:24 → 101
    Rab5ip; Rab5-interacting protein (Rab5ip)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12431.1

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