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LMO1 Lmo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850653, updated on 1-Aug-2024

Summary

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Gene symbol
LMO1
Gene description
Lmo1p
Primary source
FungiDB:YLL007C
Locus tag
YLL007C
See related
SGD:S000003930; AllianceGenome:SGD:S000003930; VEuPathDB:YLL007C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in autophagy of mitochondrion and intracellular signal transduction. Located in mitochondrion and plasma membrane. Orthologous to human ELMO1 (engulfment and cell motility 1); ELMO2 (engulfment and cell motility 2); and ELMO3 (engulfment and cell motility 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LMO1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (134302..136299, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene copper metallochaperone COX17 Neighboring gene putative ATP-dependent RNA helicase Neighboring gene uncharacterized protein Neighboring gene ERMES complex subunit MMM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Dck1 and Lmo1 as upstream regulators of the small GTPase Rho5 in Saccharomyces cerevisiae. Schmitz HP, et al. Mol Microbiol, 2015 Apr. PMID 25598154
  2. The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation. Schmitz HP, et al. Int J Mol Sci, 2018 Jul 26. PMID 30049968, Free PMC Article
  3. Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae. Yamaguchi Y, et al. Mol Microbiol, 2018 Feb. PMID 29215176
  4. Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae. Libuda DE, et al. Genetics, 2010 Apr. PMID 20139344, Free PMC Article
  5. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Lmo1p
NP_013094.1
  • Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    134302..136299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181827.1 → NP_013094.1  TPA: Lmo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXZ5, E9PAG4, Q07799
    UniProtKB/TrEMBL
    A7A0P9, G2WII8
    Conserved Domains (1) summary
    cl17171
    Location:450 → 594
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07799.1

Gene LinkOut

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