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APS1 Aps1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850868, updated on 18-Sep-2024

Summary

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Official Symbol
APS1
Official Full Name
Aps1p
Primary source
SGD:S000004160
Locus tag
YLR170C
See related
AllianceGenome:SGD:S000004160; FungiDB:YLR170C; VEuPathDB:YLR170C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YAP19
Summary
Predicted to enable clathrin adaptor activity. Involved in Golgi to vacuole transport. Part of AP-1 adaptor complex. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Orthologous to several human genes including AP1S1 (adaptor related protein complex 1 subunit sigma 1) and AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See APS1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (500579..501049, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ubiquitin-ribosomal 40S subunit protein S31 fusion protein Neighboring gene Ups2p Neighboring gene diphthine synthase Neighboring gene Tag1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins. Nakai M, et al. Biochim Biophys Acta, 1993 Sep 23. PMID 8373805
  2. The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. Phan HL, et al. EMBO J, 1994 Apr 1. PMID 8157009, Free PMC Article
  3. Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae. Phelan JP, et al. J Cell Sci, 2006 Oct 15. PMID 17003107
  4. Sorting signals that mediate traffic of chitin synthase III between the TGN/endosomes and to the plasma membrane in yeast. Starr TL, et al. PLoS One, 2012. PMID 23056294, Free PMC Article
  5. P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes. Liu K, et al. Mol Biol Cell, 2008 Aug. PMID 18508916, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drs2p acts independently of coat recruitment to facilitate AP-1/clathrin-coated vesicle budding from the TGN
    Title: P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-1 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aps1p
NP_013271.1
  • Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    500579..501049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182057.1 → NP_013271.1  TPA: Aps1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013271.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYH5, P35181
    UniProtKB/TrEMBL
    A7A162, B3RH64, B5VN89, C7GIW1, C8ZDE3, G2WJ04
    Conserved Domains (1) summary
    cd14831
    Location:5 → 149
    AP1_sigma; AP-1 complex subunit sigma
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35181.1

Gene LinkOut

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