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PIG1 protein phosphatase regulator PIG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850979, updated on 1-Aug-2024

Summary

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Gene symbol
PIG1
Gene description
protein phosphatase regulator PIG1
Primary source
FungiDB:YLR273C
Locus tag
YLR273C
See related
SGD:S000004263; AllianceGenome:SGD:S000004263; VEuPathDB:YLR273C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein phosphatase regulator activity. Involved in regulation of glycogen biosynthetic process. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to several human genes including PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PPP1R3B (protein phosphatase 1 regulatory subunit 3B); and PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PIG1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (689083..691029, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene condensin subunit YCS4 Neighboring gene tRNA-Val Neighboring gene MCM DNA helicase complex subunit MCM5 Neighboring gene mRNA splicing protein SMD2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Cheng C, et al. Yeast, 1997 Jan. PMID 9046081
  2. Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. Pačnik K, et al. BMC Genomics, 2021 Feb 9. PMID 33563210, Free PMC Article
  3. Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Castermans D, et al. Cell Res, 2012 Jun. PMID 22290422, Free PMC Article
  4. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Venturi GM, et al. Genetics, 2000 May. PMID 10790385, Free PMC Article
  5. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Papinski D, et al. Mol Cell, 2014 Feb 6. PMID 24440502, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycogen biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 1 complex ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase regulator PIG1
NP_013375.1
  • Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    689083..691029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182160.1 → NP_013375.1  TPA: protein phosphatase regulator PIG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013375.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYS0, E9P964, Q06216
    UniProtKB/TrEMBL
    C7GVT6
    Conserved Domains (1) summary
    pfam03370
    Location:192 → 331
    CBM_21; Carbohydrate/starch-binding module (family 21)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06216.1

Gene LinkOut

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