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NKP2 Nkp2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851025, updated on 18-Sep-2024

Summary

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Official Symbol
NKP2
Official Full Name
Nkp2p
Primary source
SGD:S000004307
Locus tag
YLR315W
See related
AllianceGenome:SGD:S000004307; FungiDB:YLR315W; VEuPathDB:YLR315W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in chromosome segregation. Located in kinetochore. Colocalizes with spindle pole body. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NKP2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (764808..765269)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sph1p Neighboring gene septin CDC3 Neighboring gene Tad3p Neighboring gene telomerase reverse transcriptase Neighboring gene Bud6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore. Tirupataiah S, et al. Mol Biol Rep, 2014 Feb. PMID 24385296
  2. The kinetochore prevents centromere-proximal crossover recombination during meiosis. Vincenten N, et al. Elife, 2015 Dec 14. PMID 26653857, Free PMC Article
  3. Functional dissection of a HECT ubiquitin E3 ligase. Lu JY, et al. Mol Cell Proteomics, 2008 Jan. PMID 17951556, Free PMC Article
  4. The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T. Hinshaw SM, et al. Curr Biol, 2020 Sep 7. PMID 32679099
  5. Bayesian Markov Random Field analysis for protein function prediction based on network data. Kourmpetis YA, et al. PLoS One, 2010 Feb 24. PMID 20195360, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that in kinetochore mutants like ctf19 and mcm21 the protein is mislocalized. Furthermore, removal of Nkp2 in these mutants restores normal levels of segregation.
    Title: Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Mis6-Sim4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nkp2p
NP_013419.1
  • Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    764808..765269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182204.1 → NP_013419.1  TPA: Nkp2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013419.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYV9, Q06162
    UniProtKB/TrEMBL
    A7A1K0, B3RHJ3, C7GUB6, C8ZDS8, G2WJD8
    Conserved Domains (1) summary
    pfam09447
    Location:3 → 66
    Cnl2_NKP2; Cnl2/NKP2 family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06162.1

Gene LinkOut

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