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SMC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851099, updated on 11-Sep-2024

Summary

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Official Symbol
SMC6
Primary source
SGD:S000004375
Locus tag
YLR383W
See related
AllianceGenome:SGD:S000004375; FungiDB:YLR383W; VEuPathDB:YLR383W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RHC18
Summary
Enables damaged DNA binding activity. Contributes to SUMO transferase activity. Involved in DNA double-strand break attachment to nuclear envelope; DNA recombination; and chromosome separation. Located in nucleus and site of double-strand break. Part of Smc5-Smc6 complex. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (885288..888632)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ctf3p Neighboring gene leucine--tRNA ligase NAM2 Neighboring gene Elongator subunit IKI3 Neighboring gene Swc7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Smc5/6 complex is a DNA loop-extruding motor. Pradhan B, et al. Nature, 2023 Apr. PMID 37076626, Free PMC Article
  2. Cryo-EM structure of the Smc5/6 holo-complex. Hallett ST, et al. Nucleic Acids Res, 2022 Sep 9. PMID 35993814, Free PMC Article
  3. A touching moment for Smc5/6: from ssDNA binding to repair. Ohouo PY, et al. Cell Cycle, 2011 Apr 15. PMID 21436624
  4. Anaphase onset before complete DNA replication with intact checkpoint responses. Torres-Rosell J, et al. Science, 2007 Mar 9. PMID 17347440
  5. Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. De Piccoli G, et al. Nat Cell Biol, 2006 Sep. PMID 16892052, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Smc5/6 complex is a DNA loop-extruding motor.
    Title: The Smc5/6 complex is a DNA loop-extruding motor.
  2. Cryo-EM structure of the Smc5/6 holo-complex.
    Title: Cryo-EM structure of the Smc5/6 holo-complex.
  3. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
    Title: Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
  4. Smc5/6 in the rDNA modulates lifespan independently of Fob1.
    Title: Smc5/6 in the rDNA modulates lifespan independently of Fob1​.
  5. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
    Title: Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
  6. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
  7. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
  8. Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
    Title: Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
  9. Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
    Title: Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
  10. Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
    Title: Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA double-strand break attachment to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of DNA recombination intermediates IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA repair protein SMC6
NP_013487.1
  • Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    885288..888632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182272.1 → NP_013487.1  TPA: DNA repair protein SMC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013487.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ18, Q12749
    UniProtKB/TrEMBL
    A7A1Q8, G2WJJ8, N1P1S0
    Conserved Domains (1) summary
    COG1196
    Location:81 → 1101
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12749.1

Gene LinkOut

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