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RPL6B ribosomal 60S subunit protein L6B [ Saccharomyces cerevisiae S288C ]

Gene ID: 851169, updated on 7-Jul-2024

Summary

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Gene symbol
RPL6B
Gene description
ribosomal 60S subunit protein L6B
Primary source
FungiDB:YLR448W
Locus tag
YLR448W
See related
SGD:S000004440; AllianceGenome:SGD:S000004440; VEuPathDB:YLR448W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. A structural constituent of ribosome. Involved in cytoplasmic translation and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPL6B in Genome Data Viewer
Location:
chromosome: XII
Exon count:
2
Sequence:
Chromosome: XII; NC_001144.5 (1028854..1029768)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene hexokinase Neighboring gene H(+)-transporting V0 sector ATPase subunit d Neighboring gene peptidylprolyl isomerase FPR4 Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16. Hashimoto T, et al. Biochim Biophys Acta, 1992 Sep 24. PMID 1390890
  2. GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae. Foiani M, et al. Mol Cell Biol, 1991 Jun. PMID 2038326, Free PMC Article
  3. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. Kwan EX, et al. PLoS Genet, 2013. PMID 23505383, Free PMC Article
  4. Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Rotenberg MO, et al. Genes Dev, 1988 Feb. PMID 3282992
  5. Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors. Bresson S, et al. Mol Cell, 2020 Nov 5. PMID 33053322, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L6B
NP_013553.1
  • Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1028854..1029768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182336.1 → NP_013553.1  TPA: ribosomal 60S subunit protein L6B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013553.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ82, P05739
    UniProtKB/TrEMBL
    A7A1W7, B3RHV6, C8ZE55, G2WJQ9, N1NYW5
    Conserved Domains (1) summary
    cd13156
    Location:26 → 176
    KOW_RPL6; KOW motif of Ribosomal Protein L6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05739.4

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