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SYN8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851219, updated on 11-Sep-2024

Summary

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Official Symbol
SYN8
Primary source
SGD:S000000012
Locus tag
YAL014C
See related
AllianceGenome:SGD:S000000012; FungiDB:YAL014C; VEuPathDB:YAL014C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLT2; UIP2
Summary
Enables SNAP receptor activity. Involved in Golgi to vacuole transport. Located in endosome. Orthologous to human STX8 (syntaxin 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (128252..129019, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2A structural subunit TPD3 Neighboring gene bifunctional N-glycosylase/AP lyase NTG1 Neighboring gene Rpd3L histone deacetylase complex subunit DEP1 Neighboring gene cystathionine gamma-lyase CYS3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissecting Ent3p: the ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport from endosomes. Zimmermann J, et al. Biochem J, 2010 Oct 1. PMID 20658963
  2. ENTH domain proteins are cargo adaptors for multiple SNARE proteins at the TGN endosome. Chidambaram S, et al. J Cell Sci, 2008 Feb 1. PMID 18198191
  3. Distinct contributions of vacuolar Qabc- and R-SNARE proteins to membrane fusion specificity. Izawa R, et al. J Biol Chem, 2012 Jan 27. PMID 22174414, Free PMC Article
  4. A new yeast endosomal SNARE related to mammalian syntaxin 8. Lewis MJ, et al. Traffic, 2002 Dec. PMID 12453154
  5. The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4. González Montoro A, et al. J Biol Chem, 2015 Sep 11. PMID 26224664, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi to vacuole transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
syntaxin
NP_009388.2
  • Endosomal SNARE related to mammalian syntaxin 8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    128252..129019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178159.1 → NP_009388.2  TPA: syntaxin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009388.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPK4, P31377
    UniProtKB/TrEMBL
    B5VDK9, C7GPM1, C8Z3L6, N1PAZ2
    Conserved Domains (1) summary
    cd15859
    Location:167 → 236
    SNARE_SYN8; SNARE motif of SYN8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31377.2

Gene LinkOut

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