TRM8 tRNA (guanine46-N7)-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TRM8
Official Full Name: tRNA (guanine46-N7)-methyltransferase
Primary source: SGD:S000002360
Locus tag: YDL201W
See related: AllianceGenome:SGD:S000002360; FungiDB:YDL201W; VEuPathDB:YDL201W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to tRNA (guanine-N7-)-methyltransferase activity. Involved in tRNA (guanine-N7)-methylation. Located in nucleus. Part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

a second role of Trm82p is to stabilize Trm8p in an active conformation
Title: tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA (guanine(46)-N7)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA (guanine-N7)-methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA (guanine-N7)-methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA (guanine-N7)-methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA (m7G46) methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

NP_010080.1

Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p

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The following sections contain reference sequences that belong to a specific genome build. Explain