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GYP7 GTPase-activating protein GYP7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851364, updated on 29-Jun-2024

Summary

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Gene symbol
GYP7
Gene description
GTPase-activating protein GYP7
Primary source
FungiDB:YDL234C
Locus tag
YDL234C
See related
SGD:S000002393; AllianceGenome:SGD:S000002393; VEuPathDB:YDL234C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in regulation of vacuole fusion, non-autophagic and vesicle-mediated transport. Located in cytosol. Orthologous to several human genes including TBC1D15 (TBC1 domain family member 15) and TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GYP7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (34237..36477, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 4-nitrophenylphosphatase Neighboring gene Ypd1p Neighboring gene Mfg1p Neighboring gene olichyl-diphosphooligosaccharide--protein glycotransferase OST4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Primary structure and biochemical characterization of yeast GTPase-activating proteins with substrate preference for the transport GTPase Ypt7p. Vollmer P, et al. Eur J Biochem, 1999 Feb. PMID 10091609
  2. High expression cloning, purification, and assay of Ypt-GTPase-activating proteins. Vollmer P, et al. Methods Enzymol, 1995. PMID 8583913
  3. Sequential action of two GTPases to promote vacuole docking and fusion. Eitzen G, et al. EMBO J, 2000 Dec 15. PMID 11118206, Free PMC Article
  4. TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Pan X, et al. Nature, 2006 Jul 20. PMID 16855591
  5. The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex. LaGrassa TJ, et al. J Cell Biol, 2005 Jan 31. PMID 15684030, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
    Title: The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes.
  2. Results show that the GTPase-activating protein Gyp7 inactivates the yeast vacuole Rab Ypt7 in vivo, with downstream assistance from an inhibitory casein kinase I, Yck3.
    Title: Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GTPase-activating protein GYP7
NP_010047.1
  • GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; regulates Ypt7p activity on late endosomes; contains a PH-like domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    34237..36477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180294.1 → NP_010047.1  TPA: GTPase-activating protein GYP7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010047.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRC2, P48365
    UniProtKB/TrEMBL
    A0A8H8UM70, A6ZXA0, B3LHB0, C7GJQ3, C8Z6N7, N1P7L2
    Conserved Domains (1) summary
    COG5210
    Location:134 → 738
    COG5210; GTPase-activating protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48365.1

Gene LinkOut

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