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VPS54 Vps54p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851591, updated on 1-Aug-2024

Summary

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Gene symbol
VPS54
Gene description
Vps54p
Primary source
FungiDB:YDR027C
Locus tag
YDR027C
See related
SGD:S000002434; AllianceGenome:SGD:S000002434; VEuPathDB:YDR027C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CGP1; LUV1; TCS3
Summary
Predicted to enable syntaxin binding activity. Involved in several processes, including Golgi to vacuole transport; ascospore wall assembly; and cellular sphingolipid homeostasis. Located in Golgi apparatus. Part of GARP complex. Orthologous to human VPS54 (VPS54 subunit of GARP complex). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VPS54 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (494649..497318, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S11A Neighboring gene Nsi1p Neighboring gene protein phosphatase regulator REG1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Luv1p/Rki1p/Tcs3p/Vps54p, a yeast protein that localizes to the late Golgi and early endosome, is required for normal vacuolar morphology. Conboy MJ, et al. Mol Biol Cell, 2000 Jul. PMID 10888679, Free PMC Article
  2. Regulation of tubulin polypeptides and microtubule function: Luv1p [correction of Rki1p] interacts with the beta-tubulin binding protein Rbl2p. Smith AM, et al. Chromosoma, 1998 Dec. PMID 9914379
  3. Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition. Quenneville NR, et al. Mol Biol Cell, 2006 Apr. PMID 16452629, Free PMC Article
  4. Identification, characterization and cytogenetic mapping of a yeast Vps54 homolog in rat and mouse. Walter L, et al. Gene, 2002 Feb 20. PMID 12039048
  5. Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation. Bryant NJ, et al. EMBO J, 2001 Jul 2. PMID 11432826, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular sphingolipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GARP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GARP complex IEA
Inferred from Electronic Annotation
more info
  
part_of GARP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps54p
NP_010310.1
  • Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    494649..497318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180335.1 → NP_010310.1  TPA: Vps54p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010310.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS12, Q12071
    UniProtKB/TrEMBL
    A6ZXZ0, B3LGN8, C7GLX0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12071.1

Gene LinkOut

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