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REF2 RNA-processing protein REF2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851776, updated on 18-Sep-2024

Summary

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Official Symbol
REF2
Official Full Name
RNA-processing protein REF2
Primary source
SGD:S000002603
Locus tag
YDR195W
See related
AllianceGenome:SGD:S000002603; FungiDB:YDR195W; VEuPathDB:YDR195W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity and chromatin binding activity. Involved in several processes, including RNA metabolic process; negative regulation of mRNA polyadenylation; and positive regulation of mitotic actomyosin contractile ring assembly. Located in cytosol and nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See REF2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (848599..850200)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase Neighboring gene uncharacterized protein Neighboring gene putative dephospho-CoA kinase Neighboring gene Cbs2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation. Russnak R, et al. Mol Cell Biol, 1995 Mar. PMID 7862160, Free PMC Article
  2. Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. Dheur S, et al. EMBO J, 2003 Jun 2. PMID 12773397, Free PMC Article
  3. RNA binding analysis of yeast REF2 and its two-hybrid interaction with a new gene product, FIR1. Russnak R, et al. Gene Expr, 1996. PMID 9196079, Free PMC Article
  4. Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis. Ferrer-Dalmau J, et al. Biochem J, 2010 Feb 24. PMID 20028335
  5. Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast. Morlando M, et al. EMBO J, 2004 Jun 16. PMID 15167896, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to cell division site involved in cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase II transcription, poly(A)-coupled IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-processing protein REF2
NP_010481.3
  • RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; putative regulatory subunit of type 1 protein phosphatase Glc7p, required for actomyosin ring formation, and for timely dephosphorylation and release of Bnr1p from the division site; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    848599..850200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180503.3 → NP_010481.3  TPA: RNA-processing protein REF2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010481.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSH8, P42073
    UniProtKB/TrEMBL
    B3LG88, C7GN02, C8Z5B0, N1P6J0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42073.2

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