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VPS64 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851781, updated on 11-Sep-2024

Summary

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Official Symbol
VPS64
Primary source
SGD:S000002608
Locus tag
YDR200C
See related
AllianceGenome:SGD:S000002608; FungiDB:YDR200C; VEuPathDB:YDR200C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FAR9
Summary
Involved in TOR signaling and re-entry into mitotic cell cycle after pheromone arrest. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (854279..856093, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cbs2p Neighboring gene protein-lysine N-methyltransferase Neighboring gene Spc19p Neighboring gene Rav2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. Lai F, et al. FEMS Yeast Res, 2011 Feb. PMID 20977626
  2. Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum. Pracheil T, et al. J Biol Chem, 2013 Jun 7. PMID 23625923, Free PMC Article
  3. Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy. Innokentev A, et al. Elife, 2020 Dec 15. PMID 33317697, Free PMC Article
  4. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article
  5. The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. Huang M, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760057

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TOR signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to vacuole HMP PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in re-entry into mitotic cell cycle after pheromone arrest IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps64p
NP_010486.3
  • Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog, FAR10, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    854279..856093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180508.3 → NP_010486.3  TPA: Vps64p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010486.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSI2, Q03944
    UniProtKB/TrEMBL
    A6ZYF8, B3LG84, B5VG92, N1P8D8
    Conserved Domains (2) summary
    COG1716
    Location:126 → 304
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    TIGR02168
    Location:406 → 580
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03944.1

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