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CRF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851809, updated on 11-Sep-2024

Summary

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Official Symbol
CRF1
Primary source
SGD:S000002631
Locus tag
YDR223W
See related
AllianceGenome:SGD:S000002631; FungiDB:YDR223W; VEuPathDB:YDR223W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transcription corepressor activity. Involved in negative regulation of ribosomal protein gene transcription by RNA polymerase II. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (912099..913502)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Gtb1p Neighboring gene uncharacterized protein Neighboring gene histone H2B Neighboring gene histone H2A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene duplication and the evolution of ribosomal protein gene regulation in yeast. Wapinski I, et al. Proc Natl Acad Sci U S A, 2010 Mar 23. PMID 20212107, Free PMC Article
  2. Fine-structure analysis of ribosomal protein gene transcription. Zhao Y, et al. Mol Cell Biol, 2006 Jul. PMID 16782874, Free PMC Article
  3. DNA damage regulates direct association of TOR kinase with the RNA polymerase II-transcribed HMO1 gene. Panday A, et al. Mol Biol Cell, 2017 Sep 1. PMID 28701348, Free PMC Article
  4. Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene. Joo YJ, et al. Biochim Biophys Acta, 2009 Nov-Dec. PMID 19853675
  5. Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeast. Noji T, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16600184

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Crf1p is an activator with different roles in regulation of target genes.
    Title: Yeast Crf1p is an activator with different roles in regulation of target genes.
  2. The role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae has been described.
    Title: Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.
  3. Studies confirmed the promoter occupancy of RPS3 by Rap1p and other transcription factors Sfp1p, Hmo1p and Crf1p.
    Title: Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ribosomal protein gene transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ribosomal protein gene transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of ribosomal protein gene transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Crf1p
NP_010509.1
  • Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    912099..913502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180531.1 → NP_010509.1  TPA: Crf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010509.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSK5, Q04930
    UniProtKB/TrEMBL
    B3LG64, G2WAW8, N1P6L7
    Conserved Domains (1) summary
    pfam10380
    Location:345 → 409
    CRF1; Transcription factor CRF1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04930.1

Gene LinkOut

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