COX20 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: COX20
Primary source: SGD:S000002639
Locus tag: YDR231C
See related: AllianceGenome:SGD:S000002639; FungiDB:YDR231C; VEuPathDB:YDR231C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables unfolded protein binding activity. Involved in several processes, including mitochondrial cytochrome c oxidase assembly; positive regulation of response to oxidative stress; and protein processing. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX20 (cytochrome c oxidase assembly factor COX20). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation
Title: Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation.
The Cox20 chaperone has important roles in leader peptide processing, C-tail export, and stabilization of Cox2.
Title: Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial cytochrome c oxidase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_010517.1

Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase

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The following sections contain reference sequences that belong to a specific genome build. Explain