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MRX10 Mrx10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851876, updated on 1-Aug-2024

Summary

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Gene symbol
MRX10
Gene description
Mrx10p
Primary source
FungiDB:YDR282C
Locus tag
YDR282C
See related
SGD:S000002690; AllianceGenome:SGD:S000002690; VEuPathDB:YDR282C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 11. Orthologous to human RMND1 (required for meiotic nuclear division 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MRX10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1023511..1024755, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit RRP45 Neighboring gene Phm6p Neighboring gene serine/threonine-protein kinase GCN2 Neighboring gene bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Infantile encephaloneuromyopathy and defective mitochondrial translation are due to a homozygous RMND1 mutation. Garcia-Diaz B, et al. Am J Hum Genet, 2012 Oct 5. PMID 23022099, Free PMC Article
  2. Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Kehrein K, et al. Cell Rep, 2015 Feb 17. PMID 25683707
  3. VID22 counteracts G-quadruplex-induced genome instability. Galati E, et al. Nucleic Acids Res, 2021 Dec 16. PMID 34871443, Free PMC Article
  4. Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation. Pereira F, et al. PLoS One, 2019. PMID 30682149, Free PMC Article
  5. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mrx10p
NP_010568.3
  • Mitochondrial inner membrane hypothetical protein; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1023511..1024755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180590.3 → NP_010568.3  TPA: Mrx10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010568.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSR2, Q05648
    UniProtKB/TrEMBL
    A6ZYN1, B3LG12, B5VGG0, C7GQT4, C8Z5J5, G2WB21, N1P716
    Conserved Domains (1) summary
    COG1723
    Location:32 → 405
    Rmd1; Uncharacterized protein, Rmd1/YagE family [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05648.1

Gene LinkOut

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