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NSE3 Smc5-Smc6 complex subunit NSE3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851882, updated on 1-Aug-2024

Summary

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Gene symbol
NSE3
Gene description
Smc5-Smc6 complex subunit NSE3
Primary source
FungiDB:YDR288W
Locus tag
YDR288W
See related
SGD:S000002696; AllianceGenome:SGD:S000002696; VEuPathDB:YDR288W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to SUMO transferase activity. Involved in DNA repair. Located in cytoplasm and nucleus. Part of Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in Prader-Willi syndrome. Orthologous to several human genes including MAGEA1 (MAGE family member A1); MAGEA10 (MAGE family member A10); and MAGEA11 (MAGE family member A11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NSE3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1037195..1038106)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mgp12p Neighboring gene inositol monophosphate 1-phosphatase INM2 Neighboring gene Rtt103p Neighboring gene ATP-dependent 3'-5' DNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE. Moradi-Fard S, et al. PLoS Genet, 2016 Aug. PMID 27564449, Free PMC Article
  2. Interaction of the Saccharomyces cerevisiae RING-domain protein Nse1 with Nse3 and the Smc5/6 complex is required for chromosome replication and stability. Wani S, et al. Curr Genet, 2018 Jun. PMID 29119272
  3. Smc5/6 in the rDNA modulates lifespan independently of Fob1​. Moradi-Fard S, et al. Aging Cell, 2021 Jun. PMID 33979898, Free PMC Article
  4. Genetic evidence for functional interaction of Smc5/6 complex and Top1 with spatial frequency of replication origins required for maintenance of chromosome stability. Rai R, et al. Curr Genet, 2017 Aug. PMID 28204881
  5. Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation. Taniura H, et al. Dev Growth Differ, 2015 Aug. PMID 26036668

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. nse3-1/ sir4 Delta double mutants show additive defects for telomere shortening and TPE indicating the contribution of Smc5/6 to telomere homeostasis is only in partial overlap with SIR factor silencing. These findings support a role for Smc5/6 in telomere maintenance that is separate from its canonical role(s) in HR-mediated events during replication and telomere elongation.
    Title: Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.
  2. Smc5 and Smc6 associate with each other at their hinge regions and constitute the backbone of the complex, whereas the Nse1-6 subunits form three distinct subcomplexes/entities that interact with different regions of Smc5 and Smc6.
    Title: Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to SUMO transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Smc5-Smc6 complex subunit NSE3
NP_010574.1
  • Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1037195..1038106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180596.1 → NP_010574.1  TPA: Smc5-Smc6 complex subunit NSE3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010574.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSR8, Q05541
    UniProtKB/TrEMBL
    A6ZYN7, B3LG06, B5VGG4, N1P6T2
    Conserved Domains (1) summary
    pfam01454
    Location:31 → 269
    MAGE; MAGE family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05541.1

Gene LinkOut

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