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BFR2 rRNA-processing protein BFR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851893, updated on 18-Sep-2024

Summary

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Official Symbol
BFR2
Official Full Name
rRNA-processing protein BFR2
Primary source
SGD:S000002707
Locus tag
YDR299W
See related
AllianceGenome:SGD:S000002707; FungiDB:YDR299W; VEuPathDB:YDR299W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human AATF (apoptosis antagonizing transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BFR2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1059627..1061231)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene sphingosine hydroxylase Neighboring gene F1F0 ATP synthase subunit 5 Neighboring gene glutamate 5-kinase Neighboring gene cleavage/polyadenylation factor CFT1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the yeast BFR2 gene is regulated at the transcriptional level and through degradation of its product. Chabane S, et al. Mol Gen Genet, 1998 May. PMID 9645427
  2. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Cheng J, et al. Mol Cell, 2019 Sep 19. PMID 31378463
  3. Over-expression of the yeast BFR2 gene partially suppresses the growth defects induced by Brefeldin A and by four ER-to-Golgi mutations. Chabane S, et al. Curr Genet, 1998 Jan. PMID 9472076
  4. Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes. Soltanieh S, et al. Nucleic Acids Res, 2014 Mar. PMID 24357410, Free PMC Article
  5. Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis. Moriggi G, et al. PLoS Genet, 2014 Dec. PMID 25474739, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
rRNA-processing protein BFR2
NP_010585.3
  • Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1059627..1061231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180607.3 → NP_010585.3  TPA: rRNA-processing protein BFR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010585.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSS8, Q06631, Q66RD8
    UniProtKB/TrEMBL
    A6ZYP7, B3LFZ6, C8Z5L1, N1P569
    Conserved Domains (2) summary
    pfam08164
    Location:414 → 498
    TRAUB; Apoptosis-antagonizing transcription factor, C-terminal
    pfam13339
    Location:175 → 300
    AATF-Che1; Apoptosis antagonizing transcription factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06631.1

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