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RRP17 Rrp17p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852021, updated on 29-Jun-2024

Summary

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Gene symbol
RRP17
Gene description
Rrp17p
Primary source
FungiDB:YDR412W
Locus tag
YDR412W
See related
SGD:S000002820; AllianceGenome:SGD:S000002820; VEuPathDB:YDR412W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 5'-3' exoribonuclease activity and preribosome binding activity. Involved in generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nuclear periphery. Is active in nucleolus. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RRP17 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1294693..1295400)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein-S-isoprenylcysteine carboxyl O-methyltransferase Neighboring gene Dfm1p Neighboring gene Erd1p Neighboring gene putative aminopeptidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global protein function prediction from protein-protein interaction networks. Vazquez A, et al. Nat Biotechnol, 2003 Jun. PMID 12740586
  2. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279
  3. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Tye BW, et al. Elife, 2019 Mar 7. PMID 30843788, Free PMC Article
  4. A panoramic view of yeast noncoding RNA processing. Peng WT, et al. Cell, 2003 Jun 27. PMID 12837249
  5. Puf6 primes 60S pre-ribosome nuclear export at low temperature. Gerhardy S, et al. Nat Commun, 2021 Aug 4. PMID 34349113, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rrp17p is required for efficient exonuclease digestion of the mature 5' ends of 5.8S(S) and 25S rRNAs.
    Title: Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA.
  2. Cell cycle check point proteins (Predicted)
    Title: Global protein function prediction from protein-protein interaction networks.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-3' RNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables preribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rrp17p
NP_010700.3
  • 5' exoribonuclease required for 5' end processing of pre-60S rRNA; binds late pre-60S ribosomes, accompanying them from nucleolus to nuclear periphery; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; yeast null mutant is complemented by expression of human homolog NOL12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1294693..1295400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180720.3 → NP_010700.3  TPA: Rrp17p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010700.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT44, Q04031
    UniProtKB/TrEMBL
    A0A6A5Q2X9, A6ZZ11, B3LFP2, C7GY31, C8Z5X5, G2WBF0, N1P8V2
    Conserved Domains (1) summary
    pfam09805
    Location:18 → 161
    Nop25; Nucleolar protein 12 (25kDa)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04031.1

Gene LinkOut

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