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CWC21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852093, updated on 11-Sep-2024

Summary

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Official Symbol
CWC21
Primary source
SGD:S000002890
Locus tag
YDR482C
See related
AllianceGenome:SGD:S000002890; FungiDB:YDR482C; VEuPathDB:YDR482C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mRNA splicing, via spliceosome. Part of U2-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1420431..1420838, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Dig2p Neighboring gene alkaline phosphatase PHO8 Neighboring gene alpha-1,2-mannosyltransferase KRE2 Neighboring gene Vps52p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome. Grainger RJ, et al. RNA, 2009 Dec. PMID 19854871, Free PMC Article
  2. Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection. Gautam A, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25740649, Free PMC Article
  3. The histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae. Neves LT, et al. Genes Dev, 2017 Apr 1. PMID 28446598, Free PMC Article
  4. Decrypting the Information Exchange Pathways across the Spliceosome Machinery. Saltalamacchia A, et al. J Am Chem Soc, 2020 May 6. PMID 32275149, Free PMC Article
  5. A protein map of the yeast activated spliceosome as obtained by electron microscopy. Sun C, et al. RNA, 2016 Sep. PMID 27368340, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microarray analysis shows changes in 3' splice site selection in introns in cwc21Delta cells. Propose role for Cwc21p positioning the 3' splice site at transition to the second step conformation of the spliceosome, mediated through interactions with U5 snRNP.
    Title: Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.
  2. The cwf21 domain in Cwc21p has been shown to bind directly to Prp8p
    Title: Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.
  3. results suggest multiple functions for Cwc21/SRm300 in the splicing process, including an important role in the activation of splicing in association with Isy1.
    Title: A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300.
  4. show that the N-terminus of Prp8p contains an intramolecular fold that is a Snu114p and Cwc21p interacting domain (SCwid).
    Title: Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U2-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U2-type spliceosomal complex subunit CWC21
NP_010770.3
  • Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1420431..1420838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180790.3 → NP_010770.3  TPA: U2-type spliceosomal complex subunit CWC21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010770.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTA5, Q03375
    UniProtKB/TrEMBL
    B3LFI4, C7GKS1, C8Z640, G2WBL1, N1P7M0
    Conserved Domains (1) summary
    cl40451
    Location:62 → 109
    cwf21; cwf21 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03375.1

Gene LinkOut

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