RIB3 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RIB3
Gene description: 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3
Primary source: FungiDB:YDR487C
Locus tag: YDR487C
See related: SGD:S000002895; AllianceGenome:SGD:S000002895; VEuPathDB:YDR487C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity. Involved in aerobic respiration and riboflavin biosynthetic process. Located in cytosol and mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RIB3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1428354..1428980, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

One target protein, Rib3p, which has as yet an undefined function in respiration, was confirmed to have its Cys56 reversibly S-glutathionylated in vitro in a Grx2p dependent process.
Title: Thiol redox proteomics identifies differential targets of cytosolic and mitochondrial glutaredoxin-2 isoforms in Saccharomyces cerevisiae. Reversible S-glutathionylation of DHBP synthase (RIB3).

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in riboflavin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in riboflavin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in riboflavin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3

NP_010775.1

EC 4.1.99.12

3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1428354..1428980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180795.1 → NP_010775.1 TPA: 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010775.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTB0, Q99258

UniProtKB/TrEMBL

A6ZZ76, B3LFH9, B5VH15, C7GKS5, C8Z645, G2WBL6, N1P7M6

Conserved Domains (1) summary

pfam00926
Location:6 → 205

DHBP_synthase; 3,4-dihydroxy-2-butanone 4-phosphate synthase