EUG1 protein disulfide isomerase EUG1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: EUG1
Gene description: protein disulfide isomerase EUG1
Primary source: FungiDB:YDR518W
Locus tag: YDR518W
See related: SGD:S000002926; AllianceGenome:SGD:S000002926; VEuPathDB:YDR518W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein disulfide isomerase activity; protein-disulfide reductase (glutathione) activity; and unfolded protein binding activity. Involved in protein folding. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome and autoimmune hepatitis. Orthologous to several human genes including PDIA3 (protein disulfide isomerase family A member 3) and PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein disulfide isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein disulfide isomerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein-disulfide reductase (glutathione) activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein-disulfide reductase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

NP_010806.1

Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER

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