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URC2 Urc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852133, updated on 29-Jun-2024

Summary

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Gene symbol
URC2
Gene description
Urc2p
Primary source
FungiDB:YDR520C
Locus tag
YDR520C
See related
SGD:S000002928; AllianceGenome:SGD:S000002928; VEuPathDB:YDR520C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RRT4
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in uracil catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See URC2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1481085..1483403, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase EUG1 Neighboring gene peptidylprolyl isomerase family protein FPR2 Neighboring gene Sps2p Neighboring gene putative serine/threonine protein kinase SPS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes. Andersen G, et al. J Mol Biol, 2008 Jul 18. PMID 18550080
  2. Histone acetylation and transcriptional regulation in the genome of Saccharomyces cerevisiae. Guo X, et al. Bioinformatics, 2006 Feb 15. PMID 16339282
  3. Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae. Hwang GW, et al. J Toxicol Sci, 2009 Oct. PMID 19652468
  4. Transcriptional activators in yeast. Titz B, et al. Nucleic Acids Res, 2006. PMID 16464826, Free PMC Article
  5. Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae. Hontz RD, et al. Genetics, 2009 May. PMID 19270272, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Its over expression confers resistance to cadmium in Saddharomyces cerevisiae.
    Title: Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding HDA PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytosine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrogen catabolite activation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in uracil catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Urc2p
NP_010808.3
  • Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1481085..1483403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180828.3 → NP_010808.3  TPA: Urc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010808.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTE1, Q04411
    UniProtKB/TrEMBL
    A0A8H8UP48, A6ZZA7, B3LFF0, C7GKV2, C8Z676, N1P5V7
    Conserved Domains (1) summary
    smart00066
    Location:66 → 109
    GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04411.1

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